Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging.
Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging.
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Technetium-99m hexakis 2-甲氧基异丁基异腈：人体生物分布、剂量测定、安全性以及与铊 201 用于心肌灌注成像的初步比较。
DOI：
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发表时间：
1989
影响因子：
9.3
通讯作者：
R. Fridrich
中科院分区：
文献类型：
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作者：
F. Wackers;D. Berman;J. Maddahi;D. Watson;G. Beller;Strauss Hw;C. Boucher;M. Picard;Holman Bl;R. Fridrich
在17名正常志愿者的休息和运动（I期研究）中，对一种新型心肌显像剂99mtc -hexakis-2-甲氧基异丁基异腈（HEXAMIBI）的生物分布、剂量学和安全性进行了评估。锝-99m HEXAMIBI从血液中迅速清除，具有良好的心肌摄取和有利的心肌与背景比，可用于心肌成像。剂量测定允许给药高达30 mCi （1,110 Bq）的[99mTc]HEXAMIBI。心肌图像质量较好，颗粒较少，心肌壁较201T1清晰。在一项涉及38例患者的多中心II期临床试验中，评估了[99mTc]HEXAMIBI平面应力和休息成像的临床疗效。36例明显冠心病患者中，有35例（97%）患者201T1应激图像异常，32例（89%）患者HEXAMIBI应激图像异常（P = N.S.）。tech -99m HEXAMIBI图像与31/35（86%）在201T1图像上有疤痕或缺血的患者相关。通过节段心肌分析，在463/570个心肌节段中获得了精确的一致性（81%）。这项多中心I期和II期研究表明平面[99mTc]HEXAMIBI应激显像在检测冠状动脉疾病方面是安全的，并且与201T1应激显像相比效果良好。
The biodistribution, dosimetry, and safety of a new myocardial imaging agent, 99mTc-hexakis-2-methoxyisobutyl isonitrile (HEXAMIBI), was evaluated in 17 normal volunteers at rest and exercise (Phase I studies). Technetium-99m HEXAMIBI clears rapidly from the blood with good myocardial uptake and favorable myocardial-to-background ratios for myocardial imaging. Dosimetry allows for administration of up to 30 mCi (1, 110 Bq) of [99mTc]HEXAMIBI. The myocardial images were of good quality and appeared less granular with sharper myocardial walls compared to 201T1 images. The clinical efficacy of [99mTc]HEXAMIBI planar stress and rest imaging was evaluated in a multicenter Phase II clinical trial involving 38 patients. Of 36 patients with significant coronary artery disease, 35 patients (97%) had abnormal 201T1 stress images, and 32 (89%) had abnormal [99mTc]HEXAMIBI stress images (P = N.S.). Technetium-99m HEXAMIBI images correlated in 31/35 patients (86%) who had either scar or ischemia on 201T1 images. By segmental myocardial analysis, exact concordance was obtained in 463/570 myocardial segments (81%). This multicenter Phase I and II study indicates that planar [99mTc]HEXAMIBI stress imaging is safe and compares well with 201T1 stress imaging for detection of coronary artery disease.
一种新型 Tc-99m 标记心肌显像剂，六（叔丁基异腈）-锝(I) [Tc-99m TBI]：人体初步经验。
DOI：
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发表时间：
1984
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Holman,BL;Jones,AG;Lister-James,J;Davison,A;Abrams,MJ;Kirshenbaum,JM;Tumeh,SS;English,RJ
通讯作者：
English,RJ
使用 Technetium-99m CPI 进行心肌成像：人类的初步经验。
DOI：
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发表时间：
1987
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Holman,BL;Sporn,V;Jones,AG;Sia,ST;Perez-Balino,N;Davison,A;Lister-James,J;Kronauge,JF;Mitta,AE;Camin,LL
通讯作者：
Camin,LL