Clinical practices in the pharmacological treatment of comorbid psychopathology in adolescents with alcohol use disorders
Clinical practices in the pharmacological treatment of comorbid psychopathology in adolescents with alcohol use disorders
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DOI：
10.1016/s0740-5472(03)00119-3
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发表时间：
2003-12-01
影响因子：
3.9
通讯作者：
Martin, CS
中科院分区：
文献类型：
--
作者：
Clark, DB;Wood, DS;Martin, CS
本研究调查了277名青少年在酒精使用障碍治疗中使用精神药物的情况。受试者从成瘾治疗场所，精神病项目和青少年司法机构招募。研究的特征包括特定药物的使用和适应症，1991年至2000年临床实践的变化，以及在1年随访期内继续精神药理学治疗。在基线时服用精神科药物的青少年中（n = 51），通常存在DSM-IV精神障碍，抗抑郁药的使用最常见（n = 41），苯二氮卓类药物处方罕见，约三分之一报告在1年随访时继续药物治疗。在那些共病的重度抑郁症和酒精使用障碍（n = 110），抗抑郁药物的使用显着增加，从18%到55%，在十年的研究。治疗设置并没有显着影响抗抑郁药处方的做法。在这一人群中，精神科药物的使用越来越普遍，迫切需要以经验为基础的临床指南。(C)2003年爱思唯尔公司All rights reserved.
This study examined the use of psychiatric medications in 277 adolescents in treatment for alcohol use disorders. Subjects were recruited from addictions treatment sites, psychiatric programs, and juvenile justice settings. Characteristics studied included the use of and indications for specific medications, changes in clinical practices from 1991 through 2000, and continuation of psychopharmacological treatment over a 1-year followup period. Among adolescents taking psychiatric medications at baseline (n = 51), indicated DSM-IV mental disorders were typically present, use of antidepressants was most common (n = 41), benzodiazepine prescription was rare, and about one third reported continuing pharmacological treatment at one-year followup. In those with comorbid major depressive disorder and alcohol use disorders (n = 110), antidepressant medication use increased significantly from 18% to 55% over the decade studied. The treatment setting did not significantly influence antidepressant prescribing practices. The common and increasing use of psychiatric medications in this population emphasizes the urgent need for empirically based clinical guidelines. (C) 2003 Elsevier Inc. All rights reserved.