Urinary enterolactone is associated with obesity and metabolic alteration in men in the US National Health and Nutrition Examination Survey 2001-10
Urinary enterolactone is associated with obesity and metabolic alteration in men in the US National Health and Nutrition Examination Survey 2001-10
复制标题
DOI：
10.1017/s0007114514004115
复制
发表时间：
2015-02-28
影响因子：
3.6
通讯作者：
Jiang, Zhao-Yan
中科院分区：
文献类型：
--
作者：
Xu, Cheng;Liu, Qian;Jiang, Zhao-Yan
植物雌激素是一类植物源性外源雌激素，在一些研究中已被证明可以预防癌症。植物雌激素的摄入是否会影响人群的肥胖状况尚不清楚。在本横断面研究中，我们研究了儿童和成人尿液植物雌激素代谢物与肥胖和代谢参数的关系。本研究分析了2001- 2010年参加美国国家健康与营养检查调查的1294名儿童（6-19岁）和3661名成年人（年龄0 = 20岁）的数据。采用多因素logistic回归分析BMI、腰围、血清代谢产物（总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、TAG、空腹血糖和空腹胰岛素）及代谢综合征与尿植物雌激素水平的关系。当按年龄和性别分层时，我们发现在同一调查中，成年男性（20-60岁）尿肠内酯水平与肥胖之间的相关性（OR 0.30, 95% CI 0.17, 0.54; P < 0.001）比儿童（12-19岁）或老年人（50 -60岁）更强。然而，在总体人群中未发现与尿中大豆苷元、o -去甲基安古良素、雌马酚、肠二醇或染料木素相关。我们还发现，在20-60岁的男性中，肠内酯水平的升高与TAG水平、空腹血糖水平、空腹胰岛素水平和代谢综合征呈负相关，但与高密度脂蛋白胆固醇水平呈正相关。目前的结果提供了流行病学证据，尿肠内酯与成年男性肥胖呈负相关。
Phyto-oestrogens are a family of plant-derived xeno-oestrogens that have been shown to prevent cancer in some studies. Whether phyto-oestrogen intake affects obesity status in a population is still unclear. In the present cross-sectional study, we examined the association of urinary phyto-oestrogen metabolites with obesity and metabolic parameters in children and adults. Data from 1294 children (age 6-19 years) and from 3661 adults (age >= 20 years) who participated in the US National Health and Nutrition Examination Survey 2001-10 were analysed. Multivariate logistic regression was applied to investigate the associations of BMI, waist circumference, serum metabolites (total cholesterol, HDL-cholesterol, LDL-cholesterol, TAG, fasting glucose and fasting insulin) and the metabolic syndrome with urinary phyto-oestrogen levels. When stratified by age and sex, we found a stronger association (OR 0.30, 95% CI 0.17, 0.54; P < 0.001) between urinary enterolactone levels and obesity in adult males (age 20-60 years) than in children (age 12-19 years) or the elderly (age >60 years) in the same survey. However, no associations with urinary daidzein, O-desmethylangolensin, equol, enterodiol or genistein were found in the overall population. We also found that the elevation of enterolactone levels was inversely associated with TAG levels, fasting glucose levels, fasting insulin levels and the metabolic syndrome in males aged 20-60 years, but positively associated with HDL-cholesterol levels. The present results provide epidemiological evidence that urinary enterolactone is inversely associated with obesity in adult males.