VISCOSITY OF MIXTURES OF SICKLE AND NORMAL RED-CELLS AT VARYING HEMATOCRIT LEVELS - IMPLICATIONS FOR TRANSFUSION
VISCOSITY OF MIXTURES OF SICKLE AND NORMAL RED-CELLS AT VARYING HEMATOCRIT LEVELS - IMPLICATIONS FOR TRANSFUSION
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DOI：
10.1046/j.1537-2995.1987.27387235626.x
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发表时间：
1987-05-01
期刊：
影响因子：
2.9
通讯作者：
CHIEN, S
中科院分区：
文献类型：
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作者：
SCHMALZER, EA;LEE, JO;CHIEN, S
血液悬浮液中的粘度（.eta.）受总血细胞比容水平（HT）以及细胞的可变形性的影响。这些综合因素对镰状细胞悬浮液流变学行为和输血指南的影响尚未得到充分探讨。因此，。在旋转粘度计中测定洗涤后的正常红细胞（AA）和镰状红细胞（SS）的混合物，作为SS细胞红细胞压积水平（HS）、HT、氧张力（PO2）和剪切速率的函数。比值HT：。可作为潜在供氧量的指标。随着HS或HS:HT比值的降低，最佳HT值（对于最大HT:.eta值）逐渐增大；在给定的HT下，HT：。随着HS值的降低而升高，特别是在HS值较低时。这些数据支持这样一个概念，即单纯输血对患者的益处不如换血，通过将患者的HS降至极低水平可以获得实质性的益处。发现。当HS:HT比值比HS保持不变时，HS的升高更急剧，这表明HS的绝对水平可能比HS:HT比值作为输血方案的指导更有用。
Viscosity (.eta.) in a blood suspension is affected by the total hematocrit level (HT) as well as by the deformability of the cells. The impact of these combined factors on the rheologic behavior of sickle cell suspensions and on guidelines for transfusion has not been explored fully. Therefore, the .eta. of mixtures of washed normal (AA) and sickle (SS) red cells was determined in a rotational viscosimeter as a function of the hematocrit level of SS cells (HS), HT, oxygen tension (PO2), and shear rate. The ratio HT:.eta. can be taken as an index of potential oxygen delivery. The optimal HT (for maximum HT:.eta.) became progressively higher as the HS or the HS:HT ratio was lowered; at a given HT, HT:.eta. rose with a decrease in HS, especially at low HS values. These data support the concept that simple transfusion alone is not as beneficial to the patient as exchange transfusion and that substantial benefit can be obtained by bringing the patient to very low HS levels. The finding that .eta. rose with HT more steeply when the HS:HT ratio rather than HS was held constant suggested that the absolute level of HS may be more useful than the HS:HT ratio as a guide for a transfusion regimen.