Passive broad-spectrum influenza immunoprophylaxis.
Passive broad-spectrum influenza immunoprophylaxis.
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DOI：
10.1155/2014/267594
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Sangster MY
中科院分区：
文献类型：
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作者：
Berry CM;Penhale WJ;Sangster MY
流感是一个长期存在的问题，每年影响数百万人，具有毁灭性流行病的威胁。通过接种流感病毒疫苗进行积极预防是目前的主要对策，并辅以抗病毒药物。然而，这种策略的缺点包括抗原漂移的影响，需要不断更新疫苗株组成，以及新出现的抗病毒药物耐药性。流感预防的其他选择的开发，特别是能够在大流行发作和株特异性疫苗开发之间的时期提供保护的广泛作用剂的开发，是非常令人感兴趣的。利用广谱介质可以在流感病毒暴发的早期关键阶段提供屏障保护。被动免疫有可能提供即时的抗病毒效果，抑制病毒复制，减少病毒脱落，从而在即将发生的流感大流行中保护脆弱人群。在这里，我们回顾了被动广谱流感预防方案，重点是利用自然宿主防御，包括干扰素和抗体。
Influenza is a perennial problem affecting millions of people annually with the everpresent threat of devastating pandemics. Active prophylaxis by vaccination against influenza virus is currently the main countermeasure supplemented with antivirals. However, disadvantages of this strategy include the impact of antigenic drift, necessitating constant updating of vaccine strain composition, and emerging antiviral drug resistance. The development of other options for influenza prophylaxis, particularly with broad acting agents able to provide protection in the period between the onset of a pandemic and the development of a strain specific vaccine, is of great interest. Exploitation of broad-spectrum mediators could provide barricade protection in the early critical phase of influenza virus outbreaks. Passive immunity has the potential to provide immediate antiviral effects, inhibiting virus replication, reducing virus shedding, and thereby protecting vulnerable populations in the event of an impending influenza pandemic. Here, we review passive broad-spectrum influenza prophylaxis options with a focus on harnessing natural host defenses, including interferons and antibodies.