THE SHORT-CHAIN FATTY-ACID BUTYRATE INDUCES APOPTOSIS IN COLORECTAL TUMOR-CELL LINES
THE SHORT-CHAIN FATTY-ACID BUTYRATE INDUCES APOPTOSIS IN COLORECTAL TUMOR-CELL LINES
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DOI：
10.1097/00008469-199510000-00005
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发表时间：
1995-10-01
影响因子：
2.4
通讯作者：
PARASKEVA, C
中科院分区：
文献类型：
--
作者：
HAGUE, A;PARASKEVA, C
结直肠上皮与大肠内容物接触，因此饮食因素及其自身的内部生长控制可能对生长、分化和细胞死亡的模式产生深远影响。事实上，尽管大肠癌有明显的遗传形式（Liu et al，1995），但流行病学研究表明，饮食在结直肠癌发生中起重要作用，可能是西方国家结直肠癌高发病率的主要因素。这些流行病学研究表明，这与高脂肪、低纤维饮食有关（Burkitt，1971年; Howe等人，1992年）。纤维由非淀粉多糖组成，如纤维素、半纤维素、果胶和树胶。膳食纤维可以预防结直肠癌，因为它有许多作用。增加肠道通过率和体积（从而可能降低饮食中致癌物的暴露）、吸附致癌物、改变肠道微生物菌群（因此可能改变胆盐和致癌物代谢）、改变粪便胆盐排泄、降低结肠pH值并增加结肠和直肠中短链脂肪酸的浓度（综述见McIntyre et al，1993）。淀粉和非淀粉多糖均由大肠的厌氧菌发酵，以每天至少300 mmol的速率产生短链脂肪酸（乙酸酯、丙酸酯和丁酸酯）（Cummings，1984; Cummings等人，1987）。膳食麦麸导致更高的浓度，
The colorectal epithelium is in contact with the contents of the large bowel and as a result dietary factors, as well as its own internal growth controls, may have profound effects on the patterns of growth, differentiation and cell death. Indeed, although there are clear hereditary forms of large bowel cancer (Liu et al, 1995) epidemiological studies indicate that diet plays an important role in colorectal carcinogenesis and may be a major contributory factor to the high incidence of colorectal cancer in Westernized coun-tries. These epidemiological studies suggest a link with a high-fat, low-fibre diet (Burkitt, 1971; Howe et al, 1992).Fibre consists of non-starch polysaccharides such as celluloses, hemicelluloses, pectin and gums. Dietary fibre may protect against colorectal cancer as a result of a number of effects. It increases intestinal transit rate and bulk (thereby potentially decreasing exposure to carcinogens in the diet), adsorbs carcinogens, modifies intestinal microflora (and therefore may alter bile salt and carcinogen metabolism), modifies faecal bile salt excretion, lowers the colonic pH and increases the concentrations of short-chain fatty acids in the colon and rectum (reviewed in McIntyre et al, 1993). Both starch and non-starch polysaccharides are fermented by the anaerobic bacteria of the large bowel, producing short-chain fatty acids (acetate, propionate and butyrate) at a rate of at least 300 mmol per day (Cummings, 1984; Cummings et al, 1987). Dietary wheat bran results in higher concen-