Nitrogen-Doped 4H Silicon Carbide Single-Crystal Electrode for Selective Electrochemical Sensing of Dopamine.
Nitrogen-Doped 4H Silicon Carbide Single-Crystal Electrode for Selective Electrochemical Sensing of Dopamine.
复制标题
用于多巴胺选择性电化学传感的氮掺杂 4H 碳化硅单晶电极。
DOI：
10.1021/acs.analchem.2c03609
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发表时间：
2023
影响因子：
7.4
通讯作者：
Zeng,Xiangqun
中科院分区：
文献类型：
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作者：
Fathi,Fatemeh;Sueoka,Brandon;Zhao,Feng;Zeng,Xiangqun
在这项工作中，我们设计，制造和表征了第一个氮（N）掺杂的单晶4 H碳化硅（4 H-SiC）电极用于传感神经递质多巴胺。与尿酸（UA）、抗坏血酸（AA）以及常见的阳离子（[Ru（NH3）6]3+）、阴离子（[Fe（CN）6]3-）和有机（亚甲蓝）氧化还原分子相比，该电极对多巴胺的氧化还原反应具有良好的选择性。这种独特的选择性的机制是合理的N-掺杂的4 H-SiC表面上的分析物的独特的负Si价态和吸附性能。在pH = 7.4的磷酸盐缓冲溶液中，4 H-SiC电极对多巴胺的定量电化学检测线性范围为50 nM ~ 10 μM，检测限为0.05 μM，灵敏度为3.2 nA.μM-1。此外，N掺杂的4 H-SiC电极表现出优异的电化学稳定性。这项工作为开发4 H-SiC作为下一代坚固且生物相容的神经界面材料奠定了基础，该材料适用于广泛的应用，例如神经递质的体内传感。
In this work, we designed, fabricated, and characterized the first nitrogen (N)-doped single-crystalline 4H silicon carbide (4H-SiC) electrode for sensing the neurotransmitter dopamine. This N-doped 4H-SiC electrode showed good selectivity for redox reactions of dopamine in comparison with uric acid (UA), ascorbic acid (AA), and common cationic ([Ru(NH3)6]3+), anionic ([Fe(CN)6]3–), and organic (methylene blue) redox molecules. The mechanisms of this unique selectivity are rationalized by the unique negative Si valency and adsorption properties of the analytes on the N-doped 4H-SiC surface. Quantitative electrochemical detection of dopamine by the 4H-SiC electrode was achieved in the linear range from 50 nM to 10 μM with a detection limit of 0.05 μM and a sensitivity of 3.2 nA.μM–1in a pH = 7.4 phosphate buffer solution. In addition, the N-doped 4H-SiC electrode demonstrated excellent electrochemical stability. This work forms the foundation for developing 4H-SiC as the next-generation robust and biocompatible neurointerface material for a broad range of applications such as the in vivo sensing of neurotransmitters.