Effects of Calorie Restriction in Obese Older Adults: The CROSSROADS Randomized Controlled Trial
Effects of Calorie Restriction in Obese Older Adults: The CROSSROADS Randomized Controlled Trial
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DOI：
10.1093/gerona/glw237
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发表时间：
2018-01-01
影响因子：
5.1
通讯作者：
Locher, Julie L.
中科院分区：
文献类型：
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作者：
Ard, Jamy D.;Gower, Barbara;Locher, Julie L.
背景：我们缺乏对具有心脏代谢疾病高风险的老年人热量限制的风险和益处的全面评估。卡路里限制可能会减少内脏脂肪组织（VAT），但也会对瘦体重和生活质量产生负面影响。方法：我们进行了一项为期52周的随机对照试验，涉及164名患有肥胖的老年人，他们至少服用一种治疗高脂血症、高血压或糖尿病的药物。干预措施包括单独的运动干预（exercise），或饮食调整和体重维持（maintenance），或饮食调整和能量限制（weight Loss）。主要结果是12个月后增值税的变化。次要结局包括心脏代谢危险因素、功能状态和生活质量。结果：共有148名参与者在12个月时测量了体重。尽管减少了-1.6% +/- 0.3%的体脂和4.1% +/- 0.7%的初始体重，但与运动（VAT = -21.9 +/- 173.7 cm）相比，减肥并没有统计学上更大的VAT （-192.6 +/- 185.2 cm）或瘦质量（-0.4 +/- 0.3 kg）的损失；瘦质量= 0.3 +/- 0.3 kg)。所有组的生活质量均有改善，组间无差异。身体功能未见明显变化。体重减轻对血糖有更大的改善(-8.3 +/- 3.6 mg/dL, p
Background: We lack a comprehensive assessment of the risks and benefits of calorie restriction in older adults at high risk for cardiometabolic disease. Calorie restriction may reduce visceral adipose tissue (VAT) but also have negative effects on lean mass and quality of life.Methods: We conducted a 52-week, randomized controlled trial involving 164 older adults with obesity taking at least one medication for hyperlipidemia, hypertension, or diabetes. Interventions included an exercise intervention alone (Exercise), or with diet modification and body weight maintenance (Maintenance), or with diet modification and energy restriction (Weight Loss). The primary outcome was change in VAT at 12 months. Secondary outcomes included cardiometabolic risk factors, functional status, and quality of life.Results: A total of 148 participants had measured weight at 12 months. Despite loss of -1.6% +/- 0.3% body fat and 4.1% +/- 0.7% initial body weight, Weight Loss did not have statistically greater loss of VAT (-192.6 +/- 185.2 cm(3)) or lean mass (-0.4 +/- 0.3 kg) compared with Exercise (VAT = -21.9 +/- 173.7 cm(3); lean mass = 0.3 +/- 0.3 kg). Quality of life improved in all groups with no differences between groups. No significant changes in physical function were observed. Weight Loss had significantly greater improvements in blood glucose (-8.3 +/- 3.6 mg/dL, p