Evaluation method for linking methamphetamine seizures using stable carbon and nitrogen isotopic compositions: a complementary study with impurity profiling.
Evaluation method for linking methamphetamine seizures using stable carbon and nitrogen isotopic compositions: a complementary study with impurity profiling.
复制标题
使用稳定碳和氮同位素组合物连接甲基苯丙胺缉获量的评估方法：与杂质分析的补充研究。
DOI：
10.1002/rcm.3809
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
H. Inoue
中科院分区：
文献类型：
--
作者：
Y. Iwata;K. Kuwayama;K. Tsujikawa;H. Miyaguchi;T. Kanamori;H. Inoue
药物特征分析，即从滥用药物样本中提取物理和（或）化学特征，有助于推断和确定来自相同和不同缉获的样本之间的联系，并支持毒品犯罪调查。我们描述了一种评价方法，用于连接甲基苯丙胺（MA）的缉获量，同时使用稳定的碳和氮同位素组成与气相色谱杂质分析，这是药物分析的主要方法之一。分析了在日本缉获的几套MA，其调查资料表明存在联系。各组缉获的杂质特征非常相似，分层聚类分析显示，样品分类与调查信息相对一致。MA发作的稳定碳和氮同位素组成分别在-29.40和-24.90（δ（13）C）和-2.29和5.94（δ（15）N）之间变化。在δ（13）C-δ（15）N图中，MA发作分为7组，可能反映了不同的起源。同位素组成图中簇的大小由合并的标准偏差（s（p））确定，合并的测量不确定度估计值。簇的大小小于6s（p），并且来自同位素组成的MA缉获之间的联系与杂质分析和调查信息一致。结果表明，稳定同位素组成与杂质谱的互补使用为评估癫痫发作之间的联系提供了有用的信息。
Drug profiling, extraction of physical and/or chemical profiles from abused drug samples, is useful for inferring and characterizing links between samples originating from the same and different seizures, and supports drug crime investigations. We describe an evaluation method for linking methamphetamine (MA) seizures using stable carbon and nitrogen isotopic compositions concurrently with gas chromatographic impurity profiling, which is one of the major methods of drug profiling. Several sets of MA seized in Japan, whose investigative information indicated linkages, were analyzed. The impurity profile of each set of seizures was quite similar and hierarchical cluster analysis showed a sample classification that was relatively consistent with the investigative information. The stable carbon and nitrogen isotopic compositions of the MA seizures varied between -29.40 and -24.90 (delta(13)C) and -2.29 and 5.94 (delta(15)N), respectively. In the delta(13)C-delta(15)N graph, MA seizures were classified into seven groups, probably reflecting different origins. The size of the cluster in the isotopic-composition graph was determined by pooled standard deviations (s(p)), the pooled estimates of measurement uncertainty. The sizes of the clusters were less than 6s(p) and the linkages between the MA seizures from the isotopic compositions were consistent with the impurity profiling and investigative information. The results showed that complementary use of stable-isotopic compositions with impurity profiling provides useful information for evaluating the links between seizures.