Identification and characterization of an enhancer sequence in the promoter region of human 15-lipoxygenase (15-LO) gene.
Identification and characterization of an enhancer sequence in the promoter region of human 15-lipoxygenase (15-LO) gene.
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人 15-脂氧合酶 (15-LO) 基因启动子区域增强子序列的鉴定和表征。
DOI：
10.1007/978-1-4615-4793-8_11
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发表时间：
1999
影响因子：
--
通讯作者：
Badr,K
中科院分区：
文献类型：
--
作者：
Kelavkar,U;Wang,S;Montero,A;Badr,K
脂氧合酶是脂质过氧化酶，与多种炎性疾病1 -3、膜重塑4 - 6和动脉粥样硬化形成7 -9的发病机制有关。由花生四烯酸的15-LO依赖性催化介导的人白细胞中15-（S）-羟基二十碳四烯酸[15-（S）-HETE]和脂氧素（LX）A4的形成可能代表内源性促炎和抗炎影响的组分，其最终调节炎症反应的程度和严重性1 -4，10。
Lipoxygenases are lipid-peroxidating enzymes that are implicated in the pathogenesis of a variety of inflammatory disorders1-3, membrane remodeling4-6and atheroma formation7-9. Formation of 15-(S)-hydroxyeicosatetraenoic acid [15-(S)-HETE] and lipoxin (LX) A4 in human leukocytes, mediated by15-LOdependent catalysis of arachidonic acid, likely represents a component of endogenous pro- and anti-inflammatory influences that ultimately regulate the extent and severity of inflammatory reactions1-4, 10.