NUCLEAR-BODIES (NBS) - A NEWLY REDISCOVERED ORGANELLE
NUCLEAR-BODIES (NBS) - A NEWLY REDISCOVERED ORGANELLE
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DOI：
10.1016/0014-4827(92)90068-j
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发表时间：
1992-10-01
影响因子：
3.7
通讯作者：
OCHS, RL
中科院分区：
文献类型：
--
作者：
BRASCH, K;OCHS, RL
核小体（NB）是在大约30年前通过常规电子显微镜首次详细描述的，作为主要在恶性或过度刺激的动物细胞的细胞核中发现的突出的染色质间结构。随后的研究表明，NBs是普遍存在的细胞器，但它们在数量和形态上差异很大。随着最近发现针对存在于一些NB中的几种关键核抗原的人类自身抗体，这些结构再次成为备受关注的主题。至少有一类NB，卷曲体，已被证明是核仁衍生的，不仅包含核仁相关抗原，而且还包含许多参与前mRNA剪接的snRNP组分。这些数据表明，卷曲体，也许还有其他NB，是多功能的，可能参与前mRNA和前rRNA的加工或转运。进一步的证据表明，NBs构成不同的核域的功能意义刚刚出现。
Nuclear bodies (NBs) were first described in detail some 30 years ago, by conventional electron microscopy, as prominent interchromatin structures found primarily in the nuclei of malignant or hyperstimulated animal cells. Subsequent studies have shown that NBs are ubiquitous organelles, but they are numerically and morphologically quite varied. With the recent discovery of human autoantibodies against several key nuclear antigens present in some NBs, these structures are once again the subject of much attention. At least one class of NBs, coiled bodies, has been shown to be nucleolus-derived and to contain not only nucleolus-associated antigens, but also many of the snRNP components involved in pre-mRNA splicing. These data suggest that coiled bodies, and perhaps other NBs as well, are multifunctional and may be involved in the processing or transport of both pre-mRNA and pre-rRNA. Further evidence is provided showing that NBs constitute distinct nuclear domains whose functional significance is just now emerging.