Comparison of functional outcomes and quality of life between transoral surgery and definitive chemoradiotherapy for oropharyngeal cancer
Comparison of functional outcomes and quality of life between transoral surgery and definitive chemoradiotherapy for oropharyngeal cancer
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DOI：
10.1002/hed.23610
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发表时间：
2015-03-01
影响因子：
2.9
通讯作者：
Farwell, D. Gregory
中科院分区：
文献类型：
--
作者：
Chen, Allen M.;Daly, Megan E.;Farwell, D. Gregory
背景：本研究的目的是比较最初经口切除和最终放化疗治疗口咽癌患者的预后。方法对31例经口CO2激光显微手术（16例）或机器人手术（15例）术后放疗的口咽癌患者进行回顾性分析。每例患者与1例接受明确放化疗的对照患者相匹配。比较华盛顿大学1年生活质量（UW-QOL）评分。结果1年时，除吞咽外，两组在UW-QOL各功能域均无显著差异（91.5 vs 72.1; p = 0.01）。经口手术治疗的31例患者中有23例（74%）报告吞咽良好，而化疗治疗的31例患者中有10例（32%）报告吞咽良好。结论经口手术与放化疗患者的生活质量相近。尽管后者的主观吞咽功能障碍率较高，但必须考虑混杂偏差。(c) 2014 Wiley期刊公司中国生物医学工程学报（英文版），2015
BackgroundThe purpose of this study was to compare patient-reported outcomes between patients treated by initial transoral resection versus definitive chemoradiotherapy for oropharyngeal cancer.MethodsThirty-one patients with oropharyngeal cancer treated by initial transoral CO2 laser microsurgery (n = 16) or robotic surgery (n = 15) followed by postoperative radiotherapy were identified. Each patient was matched to 1 control patient treated by definitive chemoradiotherapy. The University of Washington Quality of Life (UW-QOL) scores at 1 year were compared.ResultsNo significant differences were observed in any of the UW-QOL functional domains at 1 year with the exception of swallowing (91.5 vs 72.1; p = .01). Twenty-three of 31 patients (74%) treated by transoral surgery reported swallowing as well as ever, versus 10 of 31 patients (32%) treated by chemoradiotherapy.ConclusionSimilar quality of life was observed among patients treated by transoral surgery or chemoradiotherapy. Although the rates of subjective swallowing dysfunction were higher among the latter, confounding biases must be considered. (c) 2014 Wiley Periodicals, Inc. Head Neck 37: 381-385, 2015