Reproductive and hormonal risk factors for luminal, HER2-overexpressing, and triple-negative breast cancer in Japanese women
Reproductive and hormonal risk factors for luminal, HER2-overexpressing, and triple-negative breast cancer in Japanese women
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DOI：
10.1093/annonc/mdr613
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发表时间：
2012-09-01
影响因子：
50.5
通讯作者：
Tanaka, H.
中科院分区：
文献类型：
--
作者：
Islam, T.;Matsuo, K.;Tanaka, H.
虽然乳腺癌分子亚型的临床相关性是显而易见的，但亚型之间的病因差异尚未得到很好的确定，特别是在亚洲人中。在此，我们评估了生殖和激素特征在不同分子亚型中的病因学影响不同的假设。我们在绝经前后的日本人中进行了病例对照研究。我们检查了706例乳腺癌患者和1412例年龄和绝经状态匹配的非癌症对照。采用雌激素受体、孕激素受体和人表皮生长因子受体2（HER 2）的免疫组织化学染色将病例分为554例管腔型（激素受体阳性）、84例HER 2过表达（激素受体阴性，HER 2阳性）和68例三阴性病例（激素受体阴性，HER 2阴性）。使用多变量多分类logistic回归模型评估相关性，观察到初潮年龄与管腔疾病风险之间存在显著相关性（比值比= 1.67，95%置信区间：1.22-2.29; P趋势= 0.001）。在不同的乳腺癌分子亚型中，与产次、首次活产年龄、母乳喂养史、绝经年龄或合成激素的使用无显著差异，这些发现表明，青春期的生殖事件对日本人乳腺癌分子亚型的风险有不同的影响。
Although the clinical relevance of the molecular subtypes of breast cancer is evident, etiological differences among subtypes have not been well established, especially among Asian. Here, we evaluated the hypothesis that the etiologic impact of reproductive and hormonal features differs among molecular subtypes.We conducted a case-control study in pre- and postmenopausal Japanese. We examined 706 breast cancer patients and 1412 age- and menopausal status-matched noncancer controls. Immunohistochemical stains for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) were used to classify the cases into 554 luminal (hormone receptor positive), 84 HER2-overexpressing (hormone receptor negative, HER2 positive), and 68 triple-negative cases (hormone receptor negative, HER2 negative). Associations were evaluated using multivariate polytomous logistic regression models.A significant association was observed between early age at menarche and risk of luminal disease (odds ratios = 1.67, 95% confidence interval: 1.22-2.29; P trend = 0.001). No significant differences in association with parity, age at first live birth, breastfeeding history, age at menopause, or synthetic hormonal use were seen across molecular subtypes of breast cancer.These findings indicate that reproductive events in adolescence have differential impact on the risk of breast cancer molecular subtypes in Japanese.