Prevention of catheter-related infections: the potential of a new nano-silver impregnated catheter
Prevention of catheter-related infections: the potential of a new nano-silver impregnated catheter
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DOI：
10.1016/j.ijantimicag.2003.12.004
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发表时间：
2004-03-01
影响因子：
10.8
通讯作者：
Guggenbichler, JP
中科院分区：
文献类型：
--
作者：
Samuel, U;Guggenbichler, JP
被污染或感染的导管是医院感染的主要来源，在急诊护理医院的所有医院败血症病例中，有40%是由导管污染或感染引起的。事实证明，抗生素以及水凝胶等表面修饰在防止留置导管污染方面没有什么价值。每克10(12-13)个活性银纳米颗粒均匀分布在各种聚合物中，如聚氨酯和硅胶，在体外对广泛的微生物具有优异的抗菌活性。这些导管的结痂也显著减少。这些初步的实验数据值得临床研究。(C)2004年Elsevier B.V.和国际化疗学会。版权所有。
Contaminated or infected catheters are a major source of nosocomial infections responsible for >40% of all episodes of nosocomial sepsis in acute-care hospitals. Antibiotics as well as surface modifications with, for example, hydrogels proved to be of little value in preventing the contamination of indwelling catheters. The even distribution of 10(12-13) activated silver nanoparticles per gram in various polymers, e.g. polyurethane and silicone, results in an excellent antimicrobial activity against a broad spectrum of organisms in vitro. Substantial reduction of incrustation of these catheters was also observed. These preliminary experimental data warrant clinical studies. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.