Shorter difference between myocardium and blood optimal inversion time suggests diffuse fibrosis in dilated cardiomyopathy.
Shorter difference between myocardium and blood optimal inversion time suggests diffuse fibrosis in dilated cardiomyopathy.
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DOI：
10.1002/jmri.21953
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发表时间：
2009-11
影响因子：
4.4
通讯作者：
Manning, Warren J.
中科院分区：
文献类型：
--
作者：
Han, Yuchi;Peters, Dana C.;Dokhan, Basem;Manning, Warren J.
关键词：
通过比较扩张型心肌病（DCM）患者和健康受试者的临床晚期钆增强（LGE）心血管磁共振（CMR）研究结果，寻找DCM患者弥漫性纤维化的证据。分析20例DCM患者和17例健康对照者的LGE-CMR和Look-MRI图像。在LGE-CMR图像上测量血液SNR、心肌SNR和血液-心肌CNR。在Look-Scan图像上确定消除血液和心肌的最佳TI。使用体模研究估计造影后T1，该研究将最佳TI和心率与T1相关联。与对照组相比，DCM LGE-CMR图像上的血液SNR较低，心肌SNR较高，血液-心肌CNR较低（6.6 ± 0.7 vs. 10.3 ± 0.9，p = 0.004）。DCM患者的血液-心肌最佳TI差（ΔTI）较低（38 ± 2 ms vs. 55 ± 3 ms，p < 0.001），估计的血液-心肌T1差（ΔT1）（116 ± 6 ms vs. 152 ± 8 ms，p = 0.001）也较低。与对照组相比，DCM患者的血-心肌ΔTI和ΔT1降低，CNR降低，表明存在弥漫性纤维化。这可能会影响LGE数据的解释。
To find evidence of diffuse fibrosis in dilated cardiomyopathy (DCM) patients by comparing measurements on clinical late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) studies between DCM and healthy subjects. LGE-CMR and the Look-Locker images from 20 DCM patients and 17 healthy controls were analyzed. Blood SNR, myocardium SNR, and blood-to-myocardium CNR were measured on the LGE-CMR images. The optimal TI to null blood and myocardium was determined on the Look-Locker images. The post-contrast T1 was estimated using a phantom study which correlated optimal TI and heart rate to T1. The blood SNR was lower, myocardium SNR was higher, and the blood-to-myocardium CNR was lower (6.6 ± 0.7 vs. 10.3 ± 0.9, p = 0.004) on DCM LGE-CMR images, as compared to controls. The blood-myocardium optimal TI difference (ΔTI) was lower (38 ± 2 ms vs. 55 ± 3ms, p < 0.001) in DCM, and the estimated blood-myocardium T1 difference (ΔT1) (116 ± 6 ms vs. 152 ± 8 ms, p = 0.001) was also lower. DCM patients have reduced blood-myocardium ΔTI and ΔT1, and lower CNR as compared to controls, suggesting the presence of diffuse fibrosis. This may impact the interpretation of LGE data.
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DOI：
10.1152/ajpheart.00429.2008
发表时间：
2008-09-01
影响因子：
4.8
作者：
Jerosch-Herold, Michael;Sheridan, David C.;Hershberger, Ray E.
通讯作者：
Hershberger, Ray E.
影响因子：
24
作者：
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通讯作者：
Pennell, Dudley J.
影响因子：
158.5
作者：
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通讯作者：
Judd, RM
影响因子：
37.8
作者：
McCrohon, A;Moon, JCC;Pennell, DJ
通讯作者：
Pennell, DJ
影响因子：
1.7
作者：
Voehringer, Matthias;Mahrholdt, Heiko;Sechtem, Udo
通讯作者：
Sechtem, Udo