Signals from noncoding RNAs: Unconventional roles for conventional pol III transcripts
Signals from noncoding RNAs: Unconventional roles for conventional pol III transcripts
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来自非编码 RNA 的信号：传统 pol III 转录物的非常规作用
DOI：
10.1016/j.biocel.2012.07.013
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发表时间：
2012-11-01
影响因子：
4
通讯作者：
Shan, Ge
中科院分区：
文献类型：
--
作者：
Hu, Shanshan;Wu, Jing;Shan, Ge
一系列非编码RNA由pol III转录。其中tRNA、7SL RNA、7SK RNA、5S RNA、MRP RNA、Y RNA、Hi RNA和vault RNA等被认为是真核细胞所必需的“管家”RNA。近年来，研究人员开始认识到许多pol III转录本除了经典的“管家”作用之外还存在非常规功能。因此，这些ncRNA现在可以被视为具有功能调节信号和细胞构建模块的分子。这些非编码RNA都由pol III转录，可以组装类似于真核细胞中信号传导途径的调控网络。在这篇综述中，我们将讨论这些非常规的作用，polIII成绩单。(C)2012爱思唯尔有限公司保留所有权利。
A range of noncoding RNAs are transcribed by pol III. A lot of them such as tRNA, 7SL RNA, 7SK RNA, 5S RNA, MRP RNA, Y RNAs, Hi RNA, and vault RNAs are considered as "house keeping" RNAs essential for eukaryotic cells. In recent years, researchers started to recognize the existence of unconventional functions of many pol III transcripts other than classical "house keeping" roles. Therefore, these ncRNAs could now be viewed as molecules with functional regulatory signals as well as cellular building blocks. These noncoding RNAs, all transcribed by pol III, may assemble regulatory networks with analogy to signaling pathways in eukaryotic cells. In this review we discuss these unconventional roles of pol III transcripts. (C) 2012 Elsevier Ltd. All rights reserved.