Genome-Wide Regulatory Adaptation Shapes Population-Level Genomic Landscapes in Heliconius
Genome-Wide Regulatory Adaptation Shapes Population-Level Genomic Landscapes in Heliconius
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DOI：
10.1093/molbev/msy209
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发表时间：
2019-01-01
影响因子：
10.7
通讯作者：
Reed, Robert D.
中科院分区：
文献类型：
--
作者：
Lewis, James J.;Reed, Robert D.
顺式调节进化是生物多样化的重要引擎。虽然最近的研究已经着眼于物种间调控进化的基因组模式，但我们仍然对物种内调控变异的大小和性质缺乏了解。在这里，我们研究的进化调控元件活动在三个Heliconius erato蝴蝶种群的翅膀发展，以确定如何监管的变化与人口结构。我们发现，种内分化的染色质可及性和调节活性是丰富的，和调节变体在基因组中的空间聚集。具有强群体结构的区域高度富集调节变体，并且富集模式与发育阶段和基因表达相关。我们还发现，可变的调控元件是特别丰富的物种特异性基因组区域和长散置的核元件。我们的研究结果表明，全基因组的选择染色质的可及性和监管活动是一个重要的力量驱动模式的基因组分化的Heliconius物种。本工作也为H. erato和其他heliconlinine蝴蝶。
Cis-regulatory evolution is an important engine of organismal diversification. Although recent studies have looked at genomic patterns of regulatory evolution between species, we still have a poor understanding of the magnitude and nature of regulatory variation within species. Here, we examine the evolution of regulatory element activity over wing development in three Heliconius erato butterfly populations to determine how regulatory variation is associated with population structure. We show that intraspecific divergence in chromatin accessibility and regulatory activity is abundant, and that regulatory variants are spatially clustered in the genome. Regions with strong population structure are highly enriched for regulatory variants, and enrichment patterns are associated with developmental stage and gene expression. We also found that variable regulatory elements are particularly enriched in species-specific genomic regions and long interspersed nuclear elements. Our findings suggest that genome-wide selection on chromatin accessibility and regulatory activity is an important force driving patterns of genomic divergence within Heliconius species. This work also provides a resource for the study of gene regulatory evolution in H. erato and other heliconiine butterflies.