Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice.
Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice.
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DOI：
10.1186/1476-511x-10-202
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发表时间：
2011-11-09
影响因子：
4.5
通讯作者：
Yanagita T
中科院分区：
文献类型：
--
作者：
Tsuruta Y;Nagao K;Kai S;Tsuge K;Yoshimura T;Koganemaru K;Yanagita T
非酒精性脂肪性肝病（NAFLD）正在成为工业化国家最常见的肝病。因此，发现可以改善NAFLD的食物成分是令人感兴趣的。莲藕是莲藕的根茎，含有大量的多酚类化合物，莲藕的几种健康促进特性已被报道。在这项研究中，我们测试了是否喂食莲藕多酚提取物db/db小鼠保护他们从肝脂肪变性。喂养3周后，与对照组小鼠相比，喂食莲花多酚饲料的db/db小鼠的肝肿大和肝脏甘油三酯蓄积明显减轻。虽然脂解酶活性没有改变，脂肪酸合成酶和苹果酸酶等脂肪生成酶的活性在喂食莲花多酚的db/db小鼠中显著降低。此外，ESI-IT/MS和MALDI-TOF MS光谱揭示了多酚莲藕提取物中聚合度高达9的B型原花青素聚合物的存在。我们推测莲藕中所含的缩合单宁可以通过抑制db/db小鼠肝脏中脂肪生成酶的活性来减轻肝脏脂肪变性。
Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease of industrialized countries. Thus, discovering food components that can ameliorate NAFLD is of interest. Lotus root, the edible rhizome of Nelumbo nucifera, contains high levels of polyphenolic compounds, and several health-promoting properties of lotus root have been reported. In this study, we tested whether feeding a polyphenolic extract of lotus root to db/db mice protects them from hepatic steatosis. After 3 weeks of feeding, the hepatomegaly and hepatic triglyceride accumulation were markedly alleviated in the lotus polyphenol-diet-fed db/db mice relative to the control mice. Although the lipolytic enzyme activity was not changed, the activities of lipogenic enzymes, such as fatty acid synthase and malic enzyme, were significantly lower in the lotus polyphenol diet-fed db/db mice. Additionally, the ESI-IT/MS and MALDI-TOF MS spectra revealed the presence of B-type proanthocyanidin polymers with polymerization degree up to 9 in the polyphenolic lotus root extract. We speculate that the condensed tannins contained in lotus root can alleviate hepatic steatosis by suppressing the lipogenic enzyme activity in the livers of db/db mice.