Metal pollutants and cardiovascular disease: mechanisms and consequences of exposure.
Metal pollutants and cardiovascular disease: mechanisms and consequences of exposure.
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DOI：
10.1016/j.ahj.2014.07.007
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发表时间：
2014-12
影响因子：
4.8
通讯作者：
Lamas GA
中科院分区：
文献类型：
--
作者：
Solenkova NV;Newman JD;Berger JS;Thurston G;Hochman JS;Lamas GA
有流行病学证据表明，金属污染物可能在动脉粥样硬化及其并发症的发展中发挥作用。此外，最近的一项金属螯合剂临床试验在减少二级预防人群的心血管事件方面取得了令人惊讶的积极结果，加强了金属暴露与心血管疾病（CVD）之间的联系。因此，这是一个审查暴露于金属污染物（如砷、铅、镉和汞）是CVD的重要风险因素的证据的适当时机。我们回顾了英语医学文献，以评估和提出流行病学证据，即4种金属在人体中没有作用（异生物质），汞，铅，镉和砷，与动脉粥样硬化和CVD有流行病学和机制联系。此外，我们简要回顾了螯合疗法评估试验的结果如何加强人类动脉粥样硬化和外源性金属污染之间的联系。有强有力的证据表明，外源性金属污染与动脉粥样硬化疾病有关，是一个可改变的风险因素。
There is epidemiological evidence that metal contaminants may play a role in the development of atherosclerosis and its complications. Moreover, a recent clinical trial of a metal chelator had a surprisingly positive result in reducing cardiovascular events in a secondary prevention population, strengthening the link between metal exposure and cardiovascular disease (CVD). This is, therefore, an opportune moment to review evidence that exposure to metal pollutants, such as arsenic, lead, cadmium, and mercury, are significant risk factors for CVD. We reviewed the English-speaking medical literature to assess and present the epidemiological evidence that 4 metals having no role in the human body (xenobiotic), mercury, lead, cadmium, and arsenic, have epidemiologic and mechanistic links to atherosclerosis and CVD. Moreover, we briefly review how the results of the Trial to Assess Chelation Therapy strengthen the link between atherosclerosis and xenobiotic metal contamination in humans. There is strong evidence that xenobiotic metal contamination is linked to atherosclerotic disease and is a modifiable risk factor.