Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
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DOI：
10.1038/nn1847
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发表时间：
2007-03-01
影响因子：
25
通讯作者：
Frankland, Paul W.
中科院分区：
文献类型：
--
作者：
Kee, Nohjin;Teixeira, Catia M.;Frankland, Paul W.
在整个成年期，新的神经元不断地添加到齿状回，这是海马区的一个亚区，在空间学习中很重要。这些成人生成的颗粒细胞是否在功能上整合到记忆网络中尚不清楚。我们使用免疫组织化学方法来观察新神经元在支持完整小鼠水迷宫记忆的回路中的招募情况。我们表明，随着新的颗粒细胞成熟，它们越来越有可能被合并到支持空间记忆的电路中。到4周或更长时间时，它们比现有的颗粒细胞更有可能被招募到支持空间记忆的回路中。这种优先招募支持了新神经元对齿状回记忆处理做出独特贡献的观点。
Throughout adulthood, new neurons are continuously added to the dentate gyrus, a hippocampal subregion that is important in spatial learning. Whether these adult-generated granule cells become functionally integrated into memory networks is not known. We used immunohistochemical approaches to visualize the recruitment of new neurons into circuits supporting water maze memory in intact mice. We show that as new granule cells mature, they are increasingly likely to be incorporated into circuits supporting spatial memory. By the time the cells are 4 or more weeks of age, they are more likely than existing granule cells to be recruited into circuits supporting spatial memory. This preferential recruitment supports the idea that new neurons make a unique contribution to memory processing in the dentate gyrus.