Renoprotective Effect of Tanshinone IIA, An Active Component of Salvia miltiorrhiza, on Rats with Chronic Kidney Disease
Renoprotective Effect of Tanshinone IIA, An Active Component of Salvia miltiorrhiza, on Rats with Chronic Kidney Disease
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DOI：
10.1002/ptr.3347
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发表时间：
2010-12-01
影响因子：
7.2
通讯作者：
Lee, Byung-Cheol
中科院分区：
文献类型：
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作者：
Ahn, Young-Min;Kim, Su Kang;Lee, Byung-Cheol
慢性肾脏疾病（CKD）是终末期肾脏疾病的常见原因。抗高血压药物在临床上用于抑制CKD的进展，但不能预防最终的肾功能衰竭。本研究探讨丹参有效成分丹参酮IIA对5/6肾切除所致CKD大鼠的影响。发生肾功能不全后，给予丹参酮IIA （10 mg/kg）治疗8周。与对照组相比，丹参酮HA治疗大鼠血清肌酐、血管紧张素II （Ang II）、转化生长因子β 1 （tgf - β 1）和胶原IV水平显著降低。此外，丹参酮HA抑制CKD大鼠尿蛋白排泄的增加。这些结果表明，长期口服丹参酮IIA可以改善CKD相关的肾功能障碍。版权所有John Wiley & Sons， Ltd。
Chronic kidney disease (CKD) is a common cause of end-stage renal disease. Antihypertensive agents are used clinically to inhibit the progression of CKD, but cannot prevent eventual renal failure. This study investigated the effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, in rats suffering from CKD induced by 5/6 nephrectomy. After development of renal insufficiency, the rats were treated with Tanshinone IIA (10 mg/kg) for 8 weeks. Serum creatinine, angiotensin II (Ang II), transforming growth factor beta 1 (TGF-beta 1) and collagen IV levels were significantly reduced in Tanshinone HA treated rats compared with a control group. In addition, Tanshinone HA suppressed increases in urinary protein excretion in CKD rats. These findings suggest that chronic oral administration of Tanshinone IIA can improve renal dysfunction associated with CKD. Copyright (C) 2010 John Wiley & Sons, Ltd.