Effect of Proton-Pump Inhibitor Therapy on Serum Chromogranin A Level
Effect of Proton-Pump Inhibitor Therapy on Serum Chromogranin A Level
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DOI：
10.1159/000321535
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发表时间：
2011-01-01
期刊：
影响因子：
3.2
通讯作者：
Tulassay, Zsolt
中科院分区：
文献类型：
--
作者：
Pregun, Istvan;Herszenyi, Laszlo;Tulassay, Zsolt
背景：神经内分泌标志物，嗜铬粒蛋白A （CgA）在中长期质子泵抑制剂（PPI）治疗期间升高。目的：分析超短期和不同剂量PPI治疗对血清CgA和胃泌素水平的影响，并评价停止PPI治疗的效果。患者和方法：在28天内接受不同剂量PPI治疗的新诊断胃食管反流病（GERD）患者（n = 54）、接受PPI治疗至少6个月的患者（n = 42）和可以停止PPI治疗的受试者（n = 11）中测定空腹血清CgA和胃泌素。结果：在所有PPI剂量治疗的28天期间，5天后观察到CgA水平显著逐步升高。在标准和高剂量PPI亚组中，胃泌素也显著增加。CgA以高剂量PPI亚组升高最为显著。血清CgA和胃泌素在PPI治疗6个月后显著升高，停药5天后显著降低。结论：超短期（5天）PPI治疗后血清CgA显著升高。长期治疗后，停止PPI治疗5天足以显著降低CgA和胃泌素水平。巴塞尔S. Karger股份有限公司版权所有
Background: The neuroendocrine marker, chromogranin A (CgA) increases during medium- or long-term proton-pump inhibitor (PPI) treatment. Aims: To analyze the effect of ultra-short-term and diverse dose of PPI therapy on serum CgA and gastrin levels and evaluate the effect of PPI treatment cessation. Patients and Methods: Fasting serum CgA and gastrin were determined in newly diagnosed gastroesophageal reflux disease (GERD) patients (n = 54) treated with diverse doses of PPI during a 28-day period, in patients treated with PPIs for at least 6 months (n = 42), and in subjects where PPI treatment could be stopped (n = 11). Results: A significant stepwise increase of CgA levels was observed after 5 days during the 28-day period treatment with all PPI doses. Gastrin increased significantly also in the standard and high-dose PPI subgroups. The most prominent increase of CgA was observed in the high-dose PPI subgroup. Serum CgA and gastrin were markedly elevated after 6 months of PPI treatment, and decreased significantly after 5 days of PPI discontinuation. Conclusions: Serum CgA increases significantly even after ultra-short-term (5 days) PPI therapy. After long-term treatment, 5-day cessation of PPI therapy is sufficient to decrease significantly both CgA and gastrin levels. Copyright (C) 2011 S. Karger AG, Basel