RESPONSE PROPERTIES AND TOPOGRAPHY OF VIBRISSA-SENSITIVE VPM NEURONS IN THE RAT
RESPONSE PROPERTIES AND TOPOGRAPHY OF VIBRISSA-SENSITIVE VPM NEURONS IN THE RAT
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DOI：
10.1152/jn.1988.60.4.1181
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发表时间：
1988-10-01
影响因子：
2.5
通讯作者：
ITO, M
中科院分区：
文献类型：
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作者：
ITO, M
1.在乌拉坦麻醉下，记录了大鼠丘脑腹侧基底复合体（VB）对触须偏转的细胞外反应。从107只动物中收集了180个神经元。2. VB在细胞色素氧化酶（CO）活性反应的切片中明显分界。参照冠状切片上的33个染色点，可以定位出45个神经元。须敏感的丘脑神经元仅限于腹后内侧核（VPM）。VPM点对尾侧触须的反应位于核的背侧，而吻侧触须则投射到更深的点。背侧须行往往是代表尾VPM点，而腹侧须与更多的吻点。3.在134个神经元中，根据对维持的触须偏转的反应，记录为持续的或短暂的，50个是持续型神经元，84个是短暂型神经元。引发反应（感受野大小）的胡须的数量在神经元之间变化;在持续神经元中从1到5（中位数=1），在瞬时神经元中从1到12（中位数=4）。4.使用校准的、受控的机械刺激器来偏转单个须状物。当最有效的胡须在最优选的方向偏转时，在距离毛囊10 mm处测量阈值速度。存活细胞（n=33）阈值较低，大多数
1. Extracellular responses to whisker deflections were recorded in the rat ventrobasal thalamic complex (VB) under urethan anesthesia. One-hundred eighty neurons were collected from 107 animals. 2. VB was sharply demarcated in sections reacted for cytochrome oxidase (CO) activity. Referring to 33 dye spots identified in coronal sections, the localization of 45 neurons could be mapped out. Whisker-sensitive thalamic neurons were confined to the ventral posteromedial nucleus (VPM). VPM points responding to caudal vibrissae were localized in the dorsal aspect of the nucleus, and rostral vibrissae were found to project to deeper points. Dorsal whisker rows tended to be represented by caudal VPM points while ventral whiskers were associated with more rostral points. 3. Of 134 neurons that were noted as either sustained or transient based on the response to a maintained whisker deflection, 50 were sustained-type neurons and 84 were transient-type neurons. The number of whiskers eliciting a response (receptive-field size) varied among neurons; from 1 to 5 (median=1) among the sustained neurons and from 1 to 12 (median=4) among the transient neurons. 4. A calibrated, controlled mechanical stimulator was used to deflect individual whiskers. The threshold velocity was measured at 10 mm from the follicle of the most effective whisker when it was deflected in the most preferred direction. Sustained cells (n=33) had low threshold values, mostly