The protective effects of prostaglandin E1 in an experimental massive hepatic cell necrosis model
The protective effects of prostaglandin E1 in an experimental massive hepatic cell necrosis model
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前列腺素E1对实验性大面积肝细胞坏死模型的保护作用
DOI：
10.1002/hep.1840070603
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发表时间：
1987
期刊：
影响因子：
13.5
通讯作者：
S. Morisawa
中科院分区：
文献类型：
--
作者：
Y. Mizoguchi;H. Tsutsui;K. Miyajima;Y. Sakagami;S. Seki;Kenzo Kobayashi;Sukeo Yamamoto;S. Morisawa
当将少量革兰氏阴性脂多糖静脉注射到7天前注射了热灭活痤疮丙酸杆菌的小鼠中时，诱导了大量肝细胞坏死，大多数小鼠在24小时后死亡。然而，当前列腺素E1与脂多糖一起给药时，观察到存活率和肝脏组织学变化的显着改善。为了找出前列腺素E1如何抑制诱导大规模肝细胞坏死，在这个实验模型中，我们研究了前列腺素E1对肝粘附细胞的激活，从中释放细胞毒性因子，并对保护肝细胞免受细胞毒性因子的影响。结果，前列腺素E1不仅抑制肝粘附细胞的活化和抑制细胞毒性因子的释放，而且还直接影响肝细胞并保护它们免受细胞毒性因子的影响。
When a small amount of Gram‐negative lipopolysaccharide was intravenously injected into mice which had been injected with heat‐killed Propionibacterium acnes 7 days before, massive hepatic cell necrosis was induced and most of the mice died 24 hr later. However, when prostaglandin E1 was administered with lipopolysaccharide, remarkable improvements in the survival rate and in the histological changes of the liver were observed. In order to find out how prostaglandin E1 suppressed the induction of massive hepatic cell necrosis in this experimental model, we studied the effects of prostaglandin E1 on the activation of liver adherent cells, from which the cytotoxic factor is released, and on the protection of hepatocytes from the cytotoxic factor. As a result, prostaglandin E1 not only inhibited the activation of liver adherent cells and suppressed the release of the cytotoxic factor, but it also directly affected the hepatocytes and protected them from the cytotoxic factor.