Analysis of 9 Cases of Takotsubo Syndrome and an Analysis of the Clinical Characteristics of Takotsubo Syndrome From a Chinese Population.
Analysis of 9 Cases of Takotsubo Syndrome and an Analysis of the Clinical Characteristics of Takotsubo Syndrome From a Chinese Population.
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DOI：
10.3389/fcvm.2021.732193
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发表时间：
2021
影响因子：
3.6
通讯作者：
Ma Y
中科院分区：
文献类型：
--
作者：
Yan J;Madina M;Deng C;Yuan Q;Cao S;Xie X;Ma Y
目的：总结Takotsubo综合征的临床、血液学及影像特点。方法：收集新疆医科大学附属第一医院2015-01/2020-12收治的Takotsubo综合征患者的住院资料，总结其临床特点。通过随访明确患者结局，并对入院前后相关客观指标进行统计学分析。通过检索中国(PRISMA)收录的三个主要数据库(万方、中国知网、中国维普数据库)，总结了中国人群TTS的发病特点。结果：共纳入9例患者，其中女性6例(66.7%)。平均发病年龄46.4岁，从发病到治疗的中位时间为1天。以胸痛为主要症状8例(88.9%)，以晕厥为主要症状1例，以情绪波动或精神刺激为主要症状7例(77.8%)。入院前后对血常规、生化、凝血、心肌标志物、炎症指标、心电图客观指标进行配对T检验。研究发现，白细胞和中性粒细胞计数有统计学意义(P<；0.05)。9例患者均有QT间期延长。平均随访24±28个月，未发生不良心血管事件或复发。结论：Takotsubo综合征是一组以情绪或躯体刺激和胸痛为主要症状的临床综合征，部分伴有白细胞、中性粒细胞计数、肌酸激酶和肌钙蛋白升高，以QT间期延长和冠状动脉无明显狭窄为特征。预后总体良好，严重并发症少。
Objective: To summarize the clinical features, hematology and imaging features of Takotsubo syndrome. Methods: The hospitalization data of Takotsubo syndrome patients in the First Affiliated Hospital of Xinjiang Medical University from January 2015 to December 2020 were collected, and their clinical characteristics were summarized. Patient outcomes were clarified through follow-up visits, and relevant objective indicators were statistically analyzed before and after admission. The characteristics of TTS incidence in Chinese population were summarized by searching three (Wanfang, CNKI, China's VIP database) major databases in China (PRISMA). Results: A total of 9 patients were enrolled, including 6 females (66.7%). The mean age of onset was 46.4 years old, the median time from onset to treatment was 1 day. The main symptom of 8 cases (88.9%) was chest pain, 1 case had a main symptom of syncope, and 7 cases (77.8%) had mood fluctuations or mental stimulation as the main symptom of the disease. Paired T-tests were conducted on routine blood, biochemical, coagulation, myocardial markers, inflammatory indicators and objective indicators of ECG before and after admission. The study found that the counts of white blood cells and neutrophils were statistically significant (P < 0.05). Prolongation of the QT interval was observed in all 9 patients. After a mean follow-up of 24 ± 28 months, no adverse cardiovascular events or recurrence occurred. Conclusion: Takotsubo syndrome is a group of clinical syndromes with emotional or somatic stimulation and chest pain as the main symptoms, partly accompanied by an increase in white blood cells, neutrophilic granulocyte count, creatine kinase, and troponin and is characterized by a prolonged QT interval and no obvious coronary stenosis. The prognosis is generally good, with few serious complications.