Surface modification of hydroxyapatite by stearic acid:: characterization and in vitro behaviors
Surface modification of hydroxyapatite by stearic acid:: characterization and in vitro behaviors
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DOI：
10.1007/s10856-007-3123-5
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发表时间：
2008-01-01
影响因子：
3.7
通讯作者：
Weng, Wenjian
中科院分区：
文献类型：
--
作者：
Li, Yanbao;Weng, Wenjian
采用回流法在有机介质中用硬脂酸（Sa）对羟基磷灰石进行改性。引入活化率来表征有机溶剂、反应时间和Sa加入量对反应的影响。采用XRD、FTIR、粒度分布、TEM和ICP等方法对改性前后的HA进行了表征。Sa的最佳加入量为3wt%左右，HA表面存在Sa分子，HA与Sa发生化学反应。SA没有改变HA的物相和粒径。改性后的HA具有良好的体外生物活性。SA作为表面改性剂具有很大的潜力，可以改善有机基体中无机填料的性能。
Hydroxyapatite was modified by stearic acid (Sa) in the organic mediated solution using a reflux setup. Activation ratio was introduced to characterize the effect of organic solvents, reaction times and adding amounts of Sa. HA before and after surface modification were investigated by XRD, FTIR, particle size distribution, TEM and ICP. The optimal adding amount of Sa is about 3 wt%, and there are Sa molecules on the surface of HA with a chemical reaction between HA and Sa. Sa did not change the phases and particle size of HA. HA after modified has good bioactivity in vitro. Sa has great potential as surface modifier to improve the properties of inorganic fillers in the organic matrix.