Central regulation of gastric acid secretion: the role of neuropeptides.
Central regulation of gastric acid secretion: the role of neuropeptides.
复制标题
胃酸分泌的中枢调节：神经肽的作用。
DOI：
10.1016/0024-3205(82)90324-1
复制
发表时间：
1982
期刊：
影响因子：
6.1
通讯作者：
Stephen E. Silvis
中科院分区：
文献类型：
--
作者：
John E. Morley;Allen S. Levine;Stephen E. Silvis
多种刺激可通过中枢神经系统作用以改变胃酸分泌。损伤和刺激实验已经确定了下丘脑外侧和腹内侧以及边缘系统在胃酸分泌的中枢调节中的作用。近年来，许多神经肽已被证明可以改变胃酸分泌后，中央管理。促甲状腺激素释放激素（TRH）和胃泌素都增加胃酸分泌，而蛙皮素，降钙素，内源性阿片肽和神经降压素减少胃酸分泌。除蛙皮素外，所有其他神经肽似乎都是通过迷走神经介导的机制产生作用的。此外，这些神经肽中的一些，当集中给药时，已被证明对应激性溃疡的发展发挥有效的细胞保护作用。本文综述了胃酸分泌的肽能假说，这表明胃酸分泌的头相的最终整合是通过维持一些相互作用的肽和单胺的浓度的微妙平衡而实现的。
A variety of stimuli can act through the central nervous system to alter gastric acid secretion. Lesioning and stimulation experiments have established roles for the lateral and ventromedial hypothalamus and the limbic system in the central regulation of gastric acid secretion. Recently a number of neuropeptides have been demonstrated to alter gastric acid secretion after central administration. Thyrotropin-releasing hormone (TRH) and gastrin both increase gastric acid secretion, whereas bombesin, calcitonin, the endogenous opioid peptides and neurotensin decrease gastric acid secretion. With the exception of bombesin, all the other neuropeptides appear to produce their effects through a vagally mediated mechanism. In addition, a number of these neuropeptides, when centrally administered, have been demonstrated to exert a potent cytoprotective effect against stress ulcer development. This review develops a peptidergic hypothesis of gastric acid secretion, suggesting that the final integration of the cephalic phase of gastric acid secretion is brought about by maintaining a delicate balance in the concentration of a number of interacting peptides and monoamines.
假喂养对健康受试者和十二指肠溃疡患者胃酸分泌的影响：一些溃疡患者基础迷走神经张力增加的证据。
影响因子：
29.4
作者：
Feldman,M;Richardson,CT;Fordtran,JS
通讯作者：
Fordtran,JS