Autoantibody biomarker opens a new gateway for cancer diagnosis
Autoantibody biomarker opens a new gateway for cancer diagnosis
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DOI：
10.1016/j.bbadis.2005.12.010
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发表时间：
2006-04-01
影响因子：
6.2
通讯作者：
Cho-Chung, YS
中科院分区：
文献类型：
--
作者：
Nesterova, M;Johnson, N;Cho-Chung, YS
当前感兴趣的癌症标记物列表已大大增加，但临床工作中使用的标记物都不是真正的肿瘤标记物。这些癌症生物标志物基于肿瘤抗原的测定。在这里，我们报告了一种针对一系列血清肿瘤标志物的自身抗体酶免疫分析（EIA）筛选方法。使用受试者工作特征（ROC）图将基于自身抗体的EIA与传统抗原EIA试剂盒进行比较，结果表明自身抗体EIA可以显着增强肿瘤标志物的敏感性和特异性。如本文所证明的，对一系列血清肿瘤标志物的血清自身抗体的检测表明，大多数（如果不是全部）血清癌症生物标志物都会产生自身抗体。因此，本文提出的独特的自身抗体生物标志物筛查方法可能有助于实现癌症的准确和早期诊断。
The list of cancer markers of current interest has grown considerably, but none of the markers used in clinical work is a true tumor marker. These cancer biomarkers are based on the determination of tumor antigens. Here, we report a single method of autoantibody enzyme immunoassay (EIA) screens for a spectrum of serum tumor markers. A comparison of the autoantibody-based EIA to conventional antigen EIA kits, using receiver operating characteristic (ROC) plots, showed that the autoantibody EIA can significantly enhance the sensitivity and specificity of tumor markers. The detection of serum autoantibodies for a spectrum of serum tumor markers, as demonstrated here, suggests that most, if not all, serum cancer biomarkers produce autoantibodies. A unique autoantibody biomarker screening method, as presented here, might therefore facilitate achieving the accurate and early diagnosis of cancer.