Transport of the influenza virus genome from nucleus to nucleus.
Transport of the influenza virus genome from nucleus to nucleus.
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DOI：
10.3390/v5102424
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发表时间：
2013-10-02
期刊：
影响因子：
--
通讯作者：
Fodor E
中科院分区：
文献类型：
--
作者：
Hutchinson EC;Fodor E
流感病毒的片段基因组被封装到核糖核蛋白复合物（RNPs）中。与RNA病毒不同的是，流感病毒在被感染细胞的细胞核内复制，因此它们的RNPs必须招募宿主因子，以确保在感染过程中在多个细胞区室之间进行转运。最近的研究揭示了许多这些过程，包括核输出的调控、基因组包装、病毒粒子组装和病毒进入的机制，特别是在循环核内体上鉴定Rab11作为RNP运输和基因组组装的关键介质。本综述利用这些最新的认识成果详细描述了甲型流感病毒RNP从其在细胞核内合成到进入新宿主细胞细胞核的过程。
The segmented genome of an influenza virus is encapsidated into ribonucleoprotein complexes (RNPs). Unusually among RNA viruses, influenza viruses replicate in the nucleus of an infected cell, and their RNPs must therefore recruit host factors to ensure transport across a number of cellular compartments during the course of an infection. Recent studies have shed new light on many of these processes, including the regulation of nuclear export, genome packaging, mechanisms of virion assembly and viral entry and, in particular, the identification of Rab11 on recycling endosomes as a key mediator of RNP transport and genome assembly. This review uses these recent gains in understanding to describe in detail the journey of an influenza A virus RNP from its synthesis in the nucleus through to its entry into the nucleus of a new host cell.
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