Water dispersible magnetite nanoparticles influence the efficacy of antibiotics against planktonic and biofilm embedded Enterococcus faecalis cells
Water dispersible magnetite nanoparticles influence the efficacy of antibiotics against planktonic and biofilm embedded Enterococcus faecalis cells
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DOI：
10.1016/j.anaerobe.2013.04.013
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发表时间：
2013-08-01
期刊：
影响因子：
2.3
通讯作者：
Radulescu, Radu
中科院分区：
文献类型：
--
作者：
Chifiriuc, Mariana Carmen;Grumezescu, Alexandru Mihai;Radulescu, Radu
这项研究的目的是研究磁性纳米颗粒的潜力，同时实现持续和可控的药物释放，并随后提高抗生素对粪肠球菌的疗效。粪肠球菌是一种最具耐药性的条件致病菌，对慢性感染或免疫功能低下的患者构成威胁，很难从医疗设备中根除。据我们所知，这是第一次试图研究磁性纳米颗粒提高目前抗生素对浮游和生物膜生长的粪肠球菌的抗菌活性的能力。我们的结果表明，磁性纳米颗粒可能被认为是一种有效的氨基糖苷类抗生素载体，但需要完全了解它们与不同抗生素和细菌细胞选择性相互作用的方式，以便获得更好的策略来消除生物医学设备或人体组织上的粪肠球菌生物膜。(C)2013爱思唯尔有限公司。保留所有权利。
The objective of this study was to investigate the potential of magnetic nanoparticles to potentiate, but also to accomplish a sustained and controlled drug release and subsequently improve the efficacy of antibiotics against Enterococcus faecalis, one of the most resistant opportunistic pathogens, that poses a threat to chronically infected or immunocompromised patients and is difficult to eradicate from medical devices. To our knowledge, this is the first study trying to investigate the ability of magnetite nanoparticles to improve the anti-bacterial activity of the current antibiotics against planktonic and biofilm growing E. faecalis. Our results are suggesting that the magnetite nanoparticles may be considered an effective aminoglycoside antibiotics carrier, but a complete understanding of the way in which they selectively interact with different antibiotics and with the bacterial cell is needed, in order to obtain improved strategies for elimination of E. faecalis biofilms on biomedical devices or human tissues. (C) 2013 Elsevier Ltd. All rights reserved.