Sleep deprivation impairs spontaneous object-place but not novel-object recognition in rats
Sleep deprivation impairs spontaneous object-place but not novel-object recognition in rats
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DOI：
10.1016/j.neulet.2014.08.004
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发表时间：
2014-09-19
影响因子：
2.5
通讯作者：
Ichitani, Yukio
中科院分区：
文献类型：
--
作者：
Ishikawa, Hiroko;Yamada, Kazuo;Ichitani, Yukio
使用自发的新物体或物体位置识别测试，研究了睡眠剥夺（SD）对大鼠一次性识别记忆的影响。老鼠被允许探索一个有两个相同物体的区域。经过一段延迟时间后，它们再次被放置在同一场中，其中：（1）两个对象之一被另一个对象替换（新对象识别）； （2）将其中一个样本物体移动到不同的地方（物体位置识别），并分析它们对这些物体的探索行为。采样阶段后立即进行 4 小时的 SD（早期 SD 组）会破坏物体位置识别，但不会破坏新物体识别，而采样阶段后 4-8 小时的 SD（延迟 SD 组）不会影响任何一种范式。结果表明，睡眠选择性地促进海马依赖性记忆的巩固，并且这种作用仅限于学习后4小时内。 (C) 2014 Elsevier Ireland Ltd. 保留所有权利。
Effects of sleep deprivation (SD) on one-trial recognition memory were investigated in rats using either a spontaneous novel-object or object-place recognition test. Rats were allowed to explore a field in which two identical objects were presented. After a delay period, they were placed again in the same field in which either: (1) one of the two objects was replaced by another object (novel-object recognition); or (2) one of the sample objects was moved to a different place (object-place recognition), and their exploration behavior to these objects was analyzed. Four hours SD immediately after the sample phase (early SD group) disrupted object-place recognition but not novel-object recognition, while SD 4-8 h after the sample phase (delayed SD group) did not affect either paradigm. The results suggest that sleep selectively promotes the consolidation of hippocampal dependent memory, and that this effect is limited to within 4 h after learning. (C) 2014 Elsevier Ireland Ltd. All rights reserved.