Early trophoblast determination and stem cell maintenance in the mouse - A review
Early trophoblast determination and stem cell maintenance in the mouse - A review
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DOI：
10.1016/j.placenta.2004.01.015
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发表时间：
2004-04-01
期刊：
影响因子：
3.8
通讯作者：
Rossant, J
中科院分区：
文献类型：
--
作者：
Kunath, T;Strumpf, D;Rossant, J
哺乳动物胚胎的首要任务是与母亲建立亲密的关系。这是通过滋养层谱系的早熟分化来实现的，滋养层谱系介导子宫着床并启动胎盘形成过程。令人惊讶的是，人们对驱动桑葚胚等等卵裂球分化为滋养外胚层的分子机制知之甚少。一旦滋养层干细胞的谱系建立，人们对它的维持就会有更多的了解。本综述的前半部分将重点讨论小鼠滋养层谱系的确定，后半部分将讨论滋养层干细胞的维持。 (C) 2004 IFPA 和 Elsevier Ltd. 保留所有权利。
The first priority of a mammalian embryo is to establish an intimate relationship with its mother. This is accomplished by precocious differentiation of the trophoblast lineage, which mediates uterine implantation and initiates the process of placentation. Surprisingly little is known about the molecular mechanisms that drive trophectoderm differentiation from the equipotent blastomeres of the morula. Somewhat more is known about the maintenance of trophoblast stem cells, once this lineage has been established. The first half of this review will focus on determination of the mouse trophoblast lineage and the second half will discuss the maintenance of trophoblast stem cells. (C) 2004 IFPA and Elsevier Ltd. All rights reserved.