The phase behaviour of skin lipid mixtures based on synthetic ceramides
The phase behaviour of skin lipid mixtures based on synthetic ceramides
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DOI：
10.1016/s0009-3084(03)00050-1
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发表时间：
2003-07-01
影响因子：
3.4
通讯作者：
Bouwstra, JA
中科院分区：
文献类型：
--
作者：
de Jager, MW;Gooris, GS;Bouwstra, JA
脂质片存在于皮肤的最外层，即角质层（SC），形成了分子在皮肤上扩散的主要屏障。SC中的主要脂类是胆固醇（CHOL）、游离脂肪酸（FFA）和至少9类神经酰胺（CER），称为CER1至CER9。本研究用小广角x射线衍射研究了四种合成CER的相行为，无论是单一的还是与CHOL或CHOL和FFA混合的。脂质混合物表现出多相共存的复杂相行为。结果进一步表明，合成CER1的存在以及混合物中其他CER的适当组成对于形成具有长周期性的相至关重要，这是SC脂质相行为的特征。只有含有合成CER1和CER3、CHOL和FFA的混合物显示出与SC相似的相行为。(C) 2003 Elsevier Science Ireland Ltd.。版权所有。
The lipid lamellae present in the outermost layer of the skin, the stratum corneum (SC), form the main barrier for diffusion of molecules across the skin. The main lipid classes in SC are cholesterol (CHOL), free fatty acids (FFA) and at least nine classes of ceramides (CER), referred to as CER1 to CER9. In the present study the phase behaviour of four synthetic CER, either single or mixed with CHOL or CHOL and FFA, has been studied using small and wide angle X-ray diffraction. The lipid mixtures showed complex phase behaviour with coexistence of several phases. The results further revealed that the presence of synthetic CER1 as well as a proper composition of the other CER in the mixture were crucial for the formation of a phase with a long periodicity, characteristic for SC lipid phase behaviour. Only a mixture containing synthetic CER1 and CER3, CHOL and FFA showed similar phase behaviour to that of SC. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.