Relationship between IL-27 and coronary arterial lesions in children with Kawasaki disease
Relationship between IL-27 and coronary arterial lesions in children with Kawasaki disease
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IL-27与川崎病患儿冠状动脉病变的关系
DOI：
10.1007/s10238-017-0451-8
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发表时间：
2017-11-01
影响因子：
4.6
通讯作者：
Yi, Qijian
中科院分区：
文献类型：
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作者：
Si, Feifei;Wu, Yao;Yi, Qijian
川崎病（Kawasaki disease， KD）是由于炎症反应紊乱和免疫调节缺陷而引起的疾病。白细胞介素-27 （IL-27）是一种具有促炎和抗炎作用的新型细胞因子。本研究探讨了KD患者血清IL-27、白细胞介素- 17a （IL-17A）、白细胞介素-10 （IL-10）、白细胞介素-6 （IL-6）、白细胞介素-1β (IL-1β)、肿瘤坏死因子-α (TNF-α)水平与冠状动脉病变（CALs）的关系。我们在静脉注射免疫球蛋白（IVIG）治疗前采集了81例KD患儿的血液样本。测定251例患者IL-27、IL-17A、IL-10、IL-6、IL-1β、TNF-α水平，分为4组：正常对照组、NC组（n= 90）、发热对照组、FC组（n= 80）、无冠状动脉KD组（n= 41）和冠状动脉病变KD组（n= 40）。检测所有受试者的白细胞计数（WBC）、红细胞计数（RBC）、血红蛋白、c反应蛋白（CRP）、红细胞沉降率和降钙素原（PCT）。与发热组和对照组相比，KD组血清IL-27、IL-10、IL-17A、IL-6、IL-1β和TNF-α水平显著升高，红细胞和血红蛋白水平显著降低。血清IL-27、IL-6、IL-1β和TNF-α水平在伴有钙化的KD患儿中更高。KD患儿血清IL-27水平与WBC、CRP、PCT、IL-10、IL-17A、IL-6、TNF-α呈正相关。IL-27的上调可能与急性KD中全身性促炎标志物的上调密切相关。此外，IL-27可能参与急性KD中CALs的发展。
Kawasaki disease (KD) arises due to the disorder of the inflammation response and faulty immune regulation. Interleukin-27 (IL-27) is a novel cytokine with both pro-inflammatory and anti-inflammatory effects. This study investigated the relationship between serum levels of IL-27, Interleukin-17A (IL-17A), Interleukin-10 (IL-10), Interleukin-6 (IL-6), Interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and coronary artery lesions (CALs) in patients with KD. We obtained blood samples from 81 children with KD before intravenous immunoglobulin (IVIG) therapy. Levels of IL-27, IL-17A, IL-10, IL-6, IL-1β and TNF-α were measured in 251 cases, including 4 groups: the normal control group, NC (n= 90), febrile control, FC (n= 80), KD without coronary arteries (n= 41) and KD with coronary arterial lesions (n= 40). White blood cells counts (WBC), red blood cells counts (RBC), hemoglobin, C-reactive protein (CRP), erythrocyte sedimentation rate and procalcitonin (PCT) were tested in all subjects. Levels of IL-27, IL-10, IL-17A, IL-6, IL-1β and TNF-α were significantly elevated, and RBC and hemoglobin significantly decreased in the group of KD group compared with febrile and control groups. IL-27, IL-6, IL-1β and TNF-α serum levels are even higher in KD children with CALs. There was positive relationship between serum levels of IL-27 and WBC, CRP, PCT, IL-10, IL-17A, IL-6 and TNF-α in children with KD. The up-regulation of IL-27 may be closely linked to up-regulation of systemic pro-inflammatory markers in acute KD. Morover, IL-27 may be involved in the development of CALs in acute KD.