Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa
Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa
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DOI：
10.3389/fnbeh.2014.00346
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发表时间：
2014-10-02
影响因子：
3
通讯作者：
Ehrlich, Stefan
中科院分区：
文献类型：
--
作者：
Boehm, Ilka;Geisler, Daniel;Ehrlich, Stefan
神经性厌食症 (AN) 的病因尚不清楚。使用认知和情感任务范式调查 AN 神经特征的功能性脑成像研究的结果很难协调一致。任务相关的成像研究通常需要高度的依从性，并且只能部分探索大脑功能的分布性质和复杂性。在本研究中，使用静息态功能连接成像来研究可能与了解 AN 症状学和病因学背后的神经机制相关的特征良好的大脑网络。静息态功能磁共振成像数据从 35 名未接受药物治疗的女性急性 AN 患者和 35 名密切匹配的健康对照女性参与者 (HC) 中获得，并使用空间组独立成分分析 (ICA) 进行分解。使用经过验证的模板，我们确定了涵盖额顶叶“控制”网络、默认模式网络（DMN）、显着性网络、视觉和感觉运动网络的组件。组间比较显示，与 HC 患者相比，AN 患者角回和额顶叶网络其他部分之间的功能连接性增强。角回的连通性与自我报告的 HC 持续性呈正相关。在 DMN 中，与 HC 相比，AN 患者的前岛叶功能连接强度也有所增加。前岛叶连接与自我报告的内感受意识问题相关。这项研究是迄今为止样本量最大的研究之一，表明急性 AN 与两个主要静息状态网络 (RSN) 中的异常大脑连接有关。额板网络功能连接性增强的发现为 AN 作为一种过度认知控制障碍的概念提供了新的支持，而前岛叶与 DMN 的功能连接性增强可能反映了 AN 患者在休息时以自我和身体为中心的思考水平较高。
The etiology of anorexia nervosa (AN) is poorly understood. Results from functional brain imaging studies investigating the neural profile of AN using cognitive and emotional task paradigms are difficult to reconcile. Task related imaging studies often require a high level of compliance and can only partially explore the distributed nature and complexity of brain function. In this study, resting state functional connectivity imaging was used to investigate well-characterized brain networks potentially relevant to understand the neural mechanisms underlying the symptomatology and etiology of AN Resting state functional magnetic resonance imaging data was obtained from 35 unmedicated female acute AN patients and 35 closely matched healthy controls female participants (HC) and decomposed using spatial group independent component analyses (ICA). Using validated templates, we identified components covering the fronto-parietal "control" network, the default mode network (DMN), the salience network, the visual and the sensory motor network. Group comparison revealed an increased functional connectivity between the angular gyrus and the other parts of the fronto-parietal network in patients with AN in comparison to HC. Connectivity of the angular gyrus was positively associated with self-reported persistence in HC. In the DMN, AN patients also showed an increased functional connectivity strength in the anterior insula in comparison to HC. Anterior insula connectivity was associated with self-reported problems with interoceptive awareness. This study, with one of the largest sample to date, shows that acute AN is associated with abnormal brain connectivity in two major resting state networks (RSN). The finding of an increased functional connectivity in the fronto-panetal network adds novel support for the notion of AN as a disorder of excessive cognitive control, whereas the elevated functional connectivity of the anterior insula with the DMN may reflect the high levels of self- and body-focused ruminations when AN patients are at rest.