Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles
Near-infrared laser light mediated cancer therapy by photothermal effect of Fe3O4 magnetic nanoparticles
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通过 Fe3O4 磁性纳米粒子的光热效应进行近红外激光介导的癌症治疗
DOI：
10.1016/j.biomaterials.2013.01.086
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发表时间：
2013-05-01
期刊：
影响因子：
14
通讯作者：
Shi, Donglu
中科院分区：
文献类型：
--
作者：
Chu, Maoquan;Shao, Yuxiang;Shi, Donglu
研究了Fe_3O_4磁性纳米粒子的光热效应及其在肿瘤治疗中的作用。发现通过红色和近红外（NIR）范围的激光照射具有球形、六边形和线状形状的Fe 3 O 4纳米颗粒可以快速产生热量。这些Fe 3 O 4纳米颗粒被羧基封端的聚（乙二醇）-磷脂包覆，以增强在水中的分散性。表面功能化的Fe 3 O 4纳米粒子可以被食管癌细胞摄取，并且对细胞结构和活力没有明显影响。然而，在808 nm的照射下，食管癌细胞的活力被有效地抑制，并且当与NIR激光激活的Fe 3 O 4纳米颗粒孵育时，细胞器明显受损。小鼠食管肿瘤的生长被发现显着抑制光热效应的Fe 3 O 4纳米粒子，导致有效的肿瘤缩小。形态学检查显示，在光热治疗后，肿瘤组织结构表现出中断，细胞明显皱缩，一些细胞最终解体。(c)2013爱思唯尔有限公司版权所有。Z
The photothermal effect of Fe3O4 magnetic nanoparticles is investigated for cancer therapy both in vitro and in vivo experiments. Heat is found to be rapidly generated by red and near-infrared (NIR) range laser irradiation of Fe3O4 nanoparticles with spherical, hexagonal and wire-like shapes. These Fe3O4 nanoparticles are coated with carboxyl-terminated poly (ethylene glycol)-phospholipid for enhanced dispersion in water. The surface-functionalized Fe3O4 nanoparticles can be taken up by esophageal cancer cells and do not obviously affect the cell structure and viability. Upon irradiation at 808 nm however, the esophageal cancer cell viability is effectively suppressed, and the cellular organelles are obviously damaged when incubated with the NIR laser activated Fe3O4 nanoparticles. Mouse esophageal tumor growth was found to be significantly inhibited by the photothermal effect of Fe3O4 nanoparticles, resulting in effective tumor reduction. A morphological examination revealed that after a photothermal therapy, the tumor tissue structure exhibited discontinuation, the cells were significantly shriveled and some cells have finally disintegrated. (c) 2013 Elsevier Ltd. All rights reserved.Z