Diffuse large cell and undifferentiated lymphomas with promiment mediastinal involvement. A poor prognoctic subset of patients with non‐Hodgkin's lymphoma
Diffuse large cell and undifferentiated lymphomas with promiment mediastinal involvement. A poor prognoctic subset of patients with non‐Hodgkin's lymphoma
复制标题
具有明显纵隔受累的弥漫性大细胞和未分化淋巴瘤非霍奇金淋巴瘤患者的预后不良。
作者：
D. Trump;R. Mann
This report describes 11 adults with non‐Hodgkin's lymphoma who presented with symptoms caused by large mediastinal masses. Patients with lymphoblastic lymphoma were excluded from this analysis. Most of the patients were young women with localized disease at presentation. Ten tumors were diffuse large cell (“histiocytic”) lymphomas and one was a diffuse, undifferentiated lymphoma, non‐Burkitt's type. According to the Lukes' and Collins' classification scheme, seven were large cleaved cell type, three were large noncleaved and one was small noncleaved cell type. Sclerosis was present in four cases. Despite aggressive therapy nine patients died within 26 months of diagnosis and only two remain diseasefree. Median survival of these patients was 16 months. Patients with symptomatic mediastinal masses and non‐Hodgkin's lymphomas composed predominantly of large cell appear to share certain clinicopathologic features and to present a poor prognosis subset of patients with non‐Hodgkin's lymphoma.
