Endoscopic confocal microscopy
Endoscopic confocal microscopy
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DOI：
10.1097/01.mog.0000174217.62214.10
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发表时间：
2005-09-01
影响因子：
2.5
通讯作者：
Nishioka, NS
中科院分区：
文献类型：
--
作者：
Evans, JA;Nishioka, NS
内镜共聚焦显微镜是一种新的内镜成像技术，可以在内镜下产生高倍率的胃肠道上皮横切面图像。这些高倍图像可以使内窥镜医师在内窥镜检查中无需活检和组织病理学就能做出组织诊断。本文的目的是回顾内镜共聚焦显微镜的显著特点，描述目前的临床研究领域使用该技术，并描述其在胃肠道疾病管理中的潜在作用。这篇综述包括对该技术的概述，对描述其功能的最新出版物的回顾，以及对潜在应用的讨论。内窥镜共聚焦显微镜在技术上可行的时间很短；因此，发表的经验是有限的。描述使用内窥镜共聚焦显微镜检测发育不良组织的研究仅限于一篇论文，其中报道了内窥镜共聚焦显微镜对一般筛查人群中结肠发育不良的检测具有高度敏感性和特异性。活跃的研究领域包括检测溃疡性结肠炎和巴雷特食管的发育不良。最近的一份病例报告详细介绍了内镜共聚焦显微镜在体内检测胃幽门螺杆菌的能力。内镜共聚焦显微镜是一种新的成像技术，可以产生高倍率的胃肠道横切面图像。它在检测和管理胃肠道疾病中的作用已经在结肠癌筛查中得到了研究，目前正在各种恶性前病变中进行评估。
Purpose of review Endoscopic confocal microscopy is a new endoscopic imaging technology that produces high-magnification cross-sectional, images of the gastrointestinal epithelium during endoscopy. These high-magnification images,,might allow the endoscopist to make a tissue diagnosis during endoscopy without biopsy and histopathology. The purpose of this article is to review the salient features of endoscopic confocal microscopy, describe current clinical research areas using the technology, and depict its potential role in the management of gastrointestinal diseases. This review includes an overview of the technology, a review of recent publications describing its function, and a discussion of potential applications.Recent findings Endoscopic confocal microscopy has been technologically feasible only for a short time; therefore, the published experience is limited. Studies describing the use of endoscopic confocal microscopy for the detection of dysplastic tissue have been limited to a single paper in which endoscopic confocal microscopy was reported to be highly sensitive and specific for the detection of colonic dysplasia in a general screening population. Active areas of investigation include detecting dysplasia in ulcerative colitis and Barrett's esophagus. A recent case report detailed the ability of endoscopic confocal microscopy to detect gastric Helicobacter pylori in vivo.Summary Endoscopic confocal microscopy is a new imaging technology that produces high-magnification cross-sectional images of the gastrointestinal tract. Its role in detecting and managing diseases of the gastrointestinal tract has been studied in colon cancer screening and is currently being evaluated in a variety of premalignant conditions.