PLASTICITY OF BINAURAL INTERACTION .2. CRITICAL PERIOD AND CHANGES IN MIDLINE RESPONSE
PLASTICITY OF BINAURAL INTERACTION .2. CRITICAL PERIOD AND CHANGES IN MIDLINE RESPONSE
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DOI：
10.1152/jn.1977.40.6.1275
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发表时间：
1977-01-01
影响因子：
2.5
通讯作者：
SILVERMAN, MS
中科院分区：
文献类型：
--
作者：
CLOPTON, BM;SILVERMAN, MS
在下丘的单位被激活对侧点击。通过同等或更大强度的同侧咔嗒声抑制这种活动是成年大鼠中常见的双耳相互作用的迹象。这种双耳的相互作用是显而易见的，在单位活动的年轻大鼠在第一周后，最初的迹象，听力出现在出生后约10天。出生后10天开始单耳剥夺，持续3-5个月。取消了这种双耳交互。同样的剥夺时间，如果从30天开始，效果要小得多，如果从60天开始，效果就没有了。单位的反应，平均作为一个人口，从个别单位的中线反应的分布证明了这些变化。显然，双耳分析的神经机制需要在听力开始后的4-7周内进行经验验证。
Units in the inferior colliculus were activated by contralateral clicks. Suppression of this activity by ipsilateral clicks that were of equal or greater intensity is the commonly observed indication of binaural interaction in adult rats. Such binaural interaction was evident in the unit activity of young rats during the 1st wk after the initial indications of hearing appear at about 10 days after birth. Monaural deprivation begun at 10 days after birth and continued for 3-5 mo. abolished this binaural interaction. The same duration of deprivation had much less effect if begun at 30 days, and no effect if begun at 60 days. Unit responses, averaged as a population, and distributions of midline responses from individual units demonstrated these changes. Apparently the neural mechanisms of binaural analysis require experiential validation during the 4-7 wk after hearing begins.