Differential Gene Expression in the Nucleus Accumbens and Frontal Cortex of Lewis and Fischer 344 Rats Relevant to Drug Addiction
Differential Gene Expression in the Nucleus Accumbens and Frontal Cortex of Lewis and Fischer 344 Rats Relevant to Drug Addiction
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DOI：
10.2174/157015911795017290
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发表时间：
2011-03-01
影响因子：
5.3
通讯作者：
Ambrosio, E.
中科院分区：
文献类型：
--
作者：
Higuera-Matas, A.;Montoya, G. L.;Ambrosio, E.
吸毒成瘾是社会因素和生物因素相互作用的结果。其中，遗传变量起着重要作用。使用遗传相关的近交系大鼠品系，在他们的滥用药物的偏好不同是一个非常重要的方法来探索遗传决定因素。对刘易斯和Fischer 344大鼠进行了广泛的研究，结果表明，与Fischer 344品系相比，刘易斯品系对几种药物的成瘾性特别敏感。在这里，我们已经使用微阵列分析基因表达谱在额叶皮层和核刘易斯和费舍尔344大鼠。我们的研究结果表明，只有一个非常有限的基因组差异表达的刘易斯大鼠相比，Fischer 344株。在刘易斯品系中诱导的基因与氧转运、神经递质加工和脂肪酸代谢有关。相反，在刘易斯大鼠中被抑制的基因涉及药物和质子转运、少突胶质细胞存活和脂质过氧化等生理功能，这些数据可能有助于鉴定可能是药物滥用成瘾特性的潜在标志物的基因。
Drug addiction results from the interplay between social and biological factors. Among these, genetic variables play a major role. The use of genetically related inbred rat strains that differ in their preference for drugs of abuse is one approach of great importance to explore genetic determinants. Lewis and Fischer 344 rats have been extensively studied and it has been shown that the Lewis strain is especially vulnerable to the addictive properties of several drugs when compared with the Fischer 344 strain. Here, we have used microarrays to analyze gene expression profiles in the frontal cortex and nucleus accumbens of Lewis and Fischer 344 rats. Our results show that only a very limited group of genes were differentially expressed in Lewis rats when compared with the Fischer 344 strain. The genes that were induced in the Lewis strain were related to oxygen transport, neurotransmitter processing and fatty acid metabolism. On the contrary genes that were repressed in Lewis rats were involved in physiological functions such as drug and proton transport, oligodendrocyte survival and lipid catabolism.These data might be useful for the identification of genes which could be potential markers of the vulnerability to the addictive properties of drugs of abuse.