1H magnetic resonance imaging of normal brain tissue response to photodynamic therapy.
1H magnetic resonance imaging of normal brain tissue response to photodynamic therapy.
复制标题
正常脑组织对光动力疗法反应的 1H 磁共振成像。
DOI：
10.1097/00006123-199110000-00009
复制
发表时间：
1991
期刊：
影响因子：
4.8
通讯作者：
Hetzel,FW
中科院分区：
文献类型：
--
作者：
Jiang,Q;Knight,RA;Chopp,M;Helpern,JA;Ordidge,RJ;Qing,ZX;Hetzel,FW
1 H Magnetic resonance imaging (MRI) was used to study the effects of photodynamic therapy (PDT) on normal rat brain (n= 5) using T1-, T2-, diffusion-, and proton density (p)-weightcd images. Rats received intraperitoneal injections of 12.5 mg/kg of Photofrin II, and 48 hours later the dural area over the frontal cortex was treated with 35 J/cm 2 of light (632±1 nm). The T1-, T2-, and diffusion-weighted images revealed an evolving high contrast region of brain that corresponded to the PDT-treated area. Lesioned brain exhibited significant increases in Tl and T2 relaxation times at 1 day (P< 0.01) and 3 days (Tl. P= 0.018: T2, P< 0.01) after treatment, compared with the contralateral equivalent volume of nonlesioned brain. Water proton diffusion coefficient (D w) in the lesioned area decreased at 1 day (P= 0.026) and increased at 3 days (P= 0.012) compared with nonlesioned brain. An increase in the proton density ratio (p D/p o) from PDT (p D) versus nonlesioned side (p o) was found 3 days after PDT treatment (P= 0.03). The data indicate that the biophysical parameters obtained from magnetic resonance imaging scans. Tl, T2, D w, and proton density, can be used to monitor changes in an evolving photochemically induced lesion.(Neurosurgery 29: 538-543, 1991)
