ARCA (DYE), A GLOBAL REGULATORY GENE IN ESCHERICHIA-COLI MEDIATING REPRESSION OF ENZYMES IN AEROBIC PATHWAYS
ARCA (DYE), A GLOBAL REGULATORY GENE IN ESCHERICHIA-COLI MEDIATING REPRESSION OF ENZYMES IN AEROBIC PATHWAYS
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DOI：
10.1073/pnas.85.6.1888
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发表时间：
1988-03-01
影响因子：
11.1
通讯作者：
LIN, ECC
中科院分区：
文献类型：
--
作者：
IUCHI, S;LIN, ECC
在大肠杆菌中，许多与有氧代谢相关的酶的水平在厌氧生长期间降低。在arcA突变体中，这些酶的厌氧水平增加。由不同调节子编码的酶包括属于三羧酸循环、乙醛酸分流、脂肪酸降解途径、黄素蛋白类的几种脱氢酶和细胞色素氧化酶复合物的成员。转导杂交将arcA基因放置在染色体图谱上最小值0附近。互补试验表明，araC基因对应于染料基因，由于各种表型特性，其也被称为fexA、msp、seg或sfrA [Bachmann，B.（1983）Microbiol. Rev. 47，180-230]。一个染料缺失突变体在好氧酶系统中被去阻遏。术语“模子”被提出来描述一组受共同转录控制的调节子。
In Escherichia coli the levels of numerous enzymes associated with aerobic metabolism are decreased during anaeroic growth. In an arcA mutant the anaerobic levels of these enzymes are increased. The enzymes, which are encoded by different regulons, include members that belong to the tricarboxylic acid cycle, the glyoxylate shunt, the pathway for fatty acid degradation, several dehydrogenases of the flavoprotein class, and the cytochrome o oxidase complex. Transductional crosses placed the arcA gene near min 0 on the chromosomal map. Complementation tests showed that the araC gene corresponded to the dye genes, which is also known as fexA, msp, seg, or sfrA because of various phenotypic properties [Bachmann, B. (1983) Microbiol. Rev. 47, 180-230]. A dye-deletion mutant was derepressed in the aerobic enzyme system. The term modulon is proposed to describe a set of regulons that are subject to a common transcriptional control.