Predictors of adherence to isoniazid preventive therapy among HIV positive adults in Addis Ababa, Ethiopia
Predictors of adherence to isoniazid preventive therapy among HIV positive adults in Addis Ababa, Ethiopia
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DOI：
10.1186/1471-2458-11-916
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发表时间：
2011-12-12
影响因子：
4.5
通讯作者：
Biadgilign, Sibhatu
中科院分区：
文献类型：
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作者：
Mindachew, Mesele;Deribew, Amare;Biadgilign, Sibhatu
背景：异烟肼预防治疗(IPT)是针对结核病潜伏感染的个体进行的，以防止进展为活动性疾病。IPT失败的主要原因之一是依从性差。方法：在亚的斯亚贝巴的四家医院进行了横断面研究。数据是使用预先测试的面试者管理的结构化问卷收集的。结果：共319人(97.5%)参与本研究。在7天的回忆期内，自我报告剂量依从率为86.5%。从医护人员处获得关于IPT的解释(OR=7.74；95%CI：3.144，19.058)、在他人面前感觉良好/舒适地进行IPT[OR=5.981，95%CI(2.308，15.502)]和定期就诊(OR=4.0；95%CI：1.062，15.073)的个体更有可能坚持IPT。发生IPT相关不良反应的参与者遵守处方剂量的可能性降低93%(OR=0.065；95%CI：0.024，0.179)。结论：过去7天自我报告的剂量依从率较高。在没有获得足够的关于IPT的信息的应答者中观察到不遵守。医疗保健提供者需要加强他们的教育和咨询努力，在患者接受IPT之前说服他们。为了提高依从性，健康教育工作应侧重于IPT的重要性、方案的细节和不良反应。
Background: Isoniazide preventive therapy (IPT) is given to individuals with latent infection of tuberculosis (TB) to prevent the progression to active disease. One of the primary reasons for failure of IPT is poor adherence.Methods: A cross sectional study was conducted in four hospitals in Addis Ababa. Data were collected using a pre-tested interviewer-administered structured questionnaire. Bivariate and multivariate analysis was done to identify predictors of IPT.Results: A total of 319 (97.5%) individual participated in this study. Within seven days recall period, self-reported dose adherence rate was 86.5%. Individual who received explanation about IPT from health care providers (OR = 7.74; 95%CI: 3.144, 19.058); who had good feeling/comfortable to take IPT in front of other people [OR = 5.981, 95%CI (2.308, 15.502)] and who attended clinical appointment regularly (OR = 4.0; 95%CI: 1.062, 15.073) were more likely to adhere to IPT. Participants who developed IPT related adverse effect were 93% less likely to adhere to the prescribed doses (OR = 0.065; 95%CI: 0.024, 0.179).Conclusion: The prevalence of self reported dose adherence over the past 7 days was higher. Non-adherence was observed among respondent who were not provided with sufficient information about IPT. The health care providers need to strengthen their educational and counseling efforts to convince the patient before putting them on IPT. To enhance adherence, health education efforts should focus on the importance of IPT, the details of the regimen and adverse effects.