RESPONSES OF NERVE-FIBERS TO PULPAL INFLAMMATION AND PERIAPICAL LESIONS IN RAT MOLARS DEMONSTRATED BY CALCITONIN GENE-RELATED PEPTIDE IMMUNOCYTOCHEMISTRY
RESPONSES OF NERVE-FIBERS TO PULPAL INFLAMMATION AND PERIAPICAL LESIONS IN RAT MOLARS DEMONSTRATED BY CALCITONIN GENE-RELATED PEPTIDE IMMUNOCYTOCHEMISTRY
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DOI：
10.1016/s0099-2399(88)80054-2
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发表时间：
1988-12-01
影响因子：
4.2
通讯作者：
KIMBERLY, CL
中科院分区：
文献类型：
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作者：
KHAYAT, BG;BYERS, MR;KIMBERLY, CL
本文观察了16只成年大鼠64颗磨牙牙髓和根尖周的感觉神经纤维对炎症反应的反应。在损伤后1、5、8、11、14或21天，使用降钙素基因相关肽的免疫细胞化学对组织进行评价。存活牙髓神经支配的程度进行了研究，根尖周病变的大小进行了测量。牙髓中的神经纤维的持久性被发现到14天后受伤，而根尖周病变，早在5天后受伤。广泛发芽的神经纤维被发现在整个存活的牙髓损伤后5天，并持续在以后的组。根尖周区域的神经支配也增加了5天，在以后的时间额外发芽。降钙素基因相关肽纤维在神经源性炎症和牙齿病变的积极作用进行了讨论，以及共存的牙髓神经支配和根尖周病变的临床相关性。
The response of sensory nerve fibers to inflammation was studied in the pulp and periapex of 64 injured molars from 16 adult rats. Tissues were evaluated at 1, 5, 8, 11, 14, or 21 days after injury using immunocytochemistry for calcitonin gene-related peptide. The extent of surviving pulpal innervation was studied and the size of periapical lesions was measured. Persistence of nerve fibers in the pulp was found up to 14 days after injury, whereas periapical lesions were present as early as 5 days after injury. Extensive sprouting of the nerve fibers was found throughout the surviving pulp by 5 days after injury and persisted in later groups. Innervation of the periapical area had also increased by 5 days with additional sprouting at later times. The active role of calcitonin gene-related peptide fibers in neurogenic inflammation and dental pathosis is discussed as well as the clinical relevance of coexisting pulpal innervation and periapical lesions.