EFFECT OF LITHIUM IN MURINE IMMUNODEFICIENCY VIRUS-INFECTED ANIMALS
EFFECT OF LITHIUM IN MURINE IMMUNODEFICIENCY VIRUS-INFECTED ANIMALS
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DOI：
10.1159/000163797
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发表时间：
1993-05-01
期刊：
影响因子：
5
通讯作者：
TSE, KF
中科院分区：
文献类型：
--
作者：
GALLICCHIO, VS;CIBULL, ML;TSE, KF
老鼠艾滋病(女佣)是一种与人类艾滋病毒感染有许多相似之处的疾病。MAIDs的病原体是一种有缺陷的小鼠白血病病毒，这种病毒似乎能够在没有病毒复制的情况下诱发疾病。这一动物模型在刺激寻找问题答案和形成与人类艾滋病相关的新假说方面很有用。一价阳离子锂可以影响发生增殖和分化的多种免疫造血细胞类型和细胞过程。我们在这里描述了体内研究结果，调查锂治疗对女佣感染的小鼠的影响。病毒控制和锂处理动物的生存和发展的女佣病理监测。用锂治疗的雌性动物表现出淋巴结病和脾肿大的明显减少。女佣对照组和锂治疗组感染病毒的小鼠都出现了淋巴瘤的证据；然而，与锂治疗组小鼠相比，女佣对照组在大体和微观层面上的参与要大得多。这些数据表明，锂在调节小鼠免疫缺陷病毒感染方面可能是有效的，并提出了与锂在逆转录病毒感染相关的病理生理过程中可能发挥的潜在作用相关的重要问题。
Murine AIDS (MAIDS) is a disease that shows many similarities to human HIV infection. The etiological agent of MAIDS is a defective murine leukemia virus that seems to be able to induce disease in the absence of viral replication. This animal model has been useful in stimulating the search of answers to questions and the formation of new hypotheses related to human AIDS. The monovalent cation lithium can influence a number of immunohematopoietic cell types and cellular processes where proliferation and differentiation occur. We describe here the result of in vivo studies investigating the effect of lithium treatment on MAIDS-infected mice. Viral control and lithium-treated animals were monitored for survival and development of MAIDS pathology. MAIDS animals treated with lithium demonstrated a marked reduction in their development of lymphadenopathy and splenomegaly. Both MAIDS control and lithium-treated virus-infected mice developed evidence of lymphoma; however, the involvement was much more massive both at the gross and microscopic levels in the MAIDS control compared with the lithium-treated mice. These data suggest that lithium may be effective in modulating murine immunodeficiency virus infection and raise important questions related to the potential role lithium may play in the pathophysiological processes associated with retroviral infections.