Natural T, γδ, and NK cells in mycobacterial, Salmonella, and human immunodeficiency virus infections
Natural T, γδ, and NK cells in mycobacterial, Salmonella, and human immunodeficiency virus infections
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DOI：
10.1086/315740
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发表时间：
2000-08-01
影响因子：
6.4
通讯作者：
Jarvis, WR
中科院分区：
文献类型：
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作者：
Jason, J;Buchanan, I;Jarvis, WR
NK细胞、γ δ T细胞抗原受体链阳性细胞和CD 3（+）CD 16/56（+）（天然T [NT]）细胞参与先天免疫和免疫调节;然而，它们在临床感染中的作用尚未明确。细胞荧光分析被用来检查外周血从菌血症，非菌血症，和健康的人类免疫缺陷病毒（HIV）阳性和阴性的人在马拉维，非洲。分支杆菌血症与较高比例的CD 3（+）CD 8（-）γ δ细胞相关（中位数，16.6%与所有其他细胞的0.7%; P <0.001），沙门氏菌菌血症与较高比例的NT细胞相关（4.3%与2.2%; P = 0.002）。HIV血浆RNA水平与NT细胞（r（s）= .39; P = .002）、NK细胞（r（s）= .38; P = .003）和γ δ细胞（r（s）= .43; P < .001）呈弱正相关。与存活患者相比，死亡患者的NT细胞百分比更高（3.7% vs. 1.9%; P = 0.017），自发产生干扰素-γ的NT细胞百分比更高（2.4% vs. 1.2%; P = 0.035）。这些数据支持γ δ和NT细胞在分枝杆菌、沙门氏菌和HIV感染中的临床相关性，以及NT细胞在死亡率中的临床相关性。
NK cells, gamma delta T cell antigen receptor chain-positive cells, and CD3(+)CD16/56(+) (natural T [NT]) cells are involved in innate immunity and immunoregulation; however, their role in clinical infection is not well defined. Cytofluorometric analysis was used to examine peripheral blood from bacteremic, nonbacteremic, and healthy human immunodeficiency virus (HIV)-positive and -negative persons in Malawi, Africa. Mycobacteremia was associated with a higher proportion of CD3(+)CD8(-) gamma delta cells (median, 16.6% a vs. 0.7% for all other cells; P < .001), and Salmonella bacteremia was associated with a higher proportion of NT cells (4.3% vs. 2.2%; P = .002). HIV plasma RNA levels were weakly positively correlated with NT cells (r(s) = .39; P = .002), NK cells (r(s) = .38; P = .003), and gamma delta cells (r(s) = .43; P < .001). Compared with patients who survived, patients who died had a higher percentage of NT cells (3.7% vs. 1.9%; P = .017) and a higher percentage of NT cells that spontaneously produced interferon-gamma (2.4% vs. 1.2%; P = .035). The data support the clinical relevance of gamma delta and NT cells in mycobacterial, Salmonella, and HIV infections and of NT cells in mortality.