Update on HER-2 as a target for cancer therapy: the ERBB2 promoter and its exploitation for cancer treatment.
Update on HER-2 as a target for cancer therapy: the ERBB2 promoter and its exploitation for cancer treatment.
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DOI：
10.1186/bcr329
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Hurst HC
中科院分区：
文献类型：
--
作者：
Hurst HC
ERBB 2原癌基因的过表达与乳腺癌中该基因的扩增有关，但启动子活性的增加也起着重要作用。两个转录因子家族（AP-2和Ets）的成员在过表达细胞中显示与启动子的结合增加。因此，已经设计了通过这些因子的DNA结合位点或通过另一种启动子序列（聚嘌呤-聚嘧啶重复结构）靶向启动子活性的策略。该启动子还因其肿瘤特异性活性而被开发用于引导细胞毒性化合物选择性地在癌细胞内积累。我们目前对ERBB 2启动子的理解进行了综述，并讨论了这些治疗途径的现状。
Overexpression of the ERBB2 proto-oncogene is associated with amplification of the gene in breast cancer but increased activity of the promoter also plays a significant role. Members of two transcription factor families (AP-2 and Ets) show increased binding to the promoter in over-expressing cells. Consequently, strategies have been devised to target promoter activity, either through the DNA binding sites for these factors, or through another promoter sequence, a polypurine-polypyrimidine repeat structure. The promoter has also been exploited for its tumour-specific activity to direct the accumulation of cytotoxic compounds selectively within cancer cells. Our current understanding of the ERBB2 promoter is reviewed and the status of these therapeutic avenues is discussed.
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影响因子：
11.4
作者：
Balda, MS;Matter, K
通讯作者：
Matter, K
影响因子：
6.4
作者：
Stackhouse, MA;Buchsbaum, DJ;Curiel, DT
通讯作者：
Curiel, DT
影响因子：
4.8
作者：
Chiang, SY;Bürli, RW;Beerman, TA
通讯作者：
Beerman, TA
影响因子：
2.5
作者：
Bates, Nicholas P.;Hurst, Helen C.
通讯作者：
Hurst, Helen C.
DOI：
10.1006/bbrc.1999.0634
发表时间：
1999-05-19
影响因子：
3.1
作者：
Nezu, M;Sasaki, H;Terada, M
通讯作者：
Terada, M