Metabolic syndrome and associated factors in Iranian children and adolescents: the CASPIAN-V study
Metabolic syndrome and associated factors in Iranian children and adolescents: the CASPIAN-V study
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DOI：
10.15171/jcvtr.2018.37
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发表时间：
2018-01-01
影响因子：
1.1
通讯作者：
Kelishadi, Roya
中科院分区：
文献类型：
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作者：
Heshmat, Ramin;Hemati, Zeinab;Kelishadi, Roya
前言：代谢综合征(METS)是儿童和青少年常见的代谢紊乱之一。这项研究旨在评估具有全国代表性的伊朗儿科年龄组样本中的METS发生率及其相关因素。3方法：这项全国性的横断面研究于2015年在伊朗30个省进行。参与者包括4,200名7-18岁的在校学生，他们参加了一项全国性的校本监测项目(里海-V)。使用标准方案进行体检和实验室测试。对3834名学生进行血液生化检测。结果：采血参与率为91.5%。MET在城市学生中的患病率显著高于农村学生(5.7%比4.8%，P值均<0.01)。在父母肥胖的学生中，代谢综合征的患病率高于父母非肥胖的学生(6.4%比4.5%，P值<0.05)。在控制潜在的混杂因素后，中等水平的健康营养行为与METS显著相关(优势比[OR]：0.62，95%CI：0.40~0.98)。营养不良行为发生率高的学生在粗营养(OR：1.6，95%CI：1.05~2.44)和调整后的营养模式(OR：1.65，95%CI：1.05~2.63)中患METS的风险较高。结论：伊朗儿童年龄组的METS患病率及相关危险因素较高，且男生患病率较高。这些发现为有效的预防策略提供了有用的信息，这些策略基于饮食、运动和生活方式的改变，而不是治疗方式。
Introduction: Metabolic syndrome (MetS) is one of the common metabolic disorders seen in children and adolescents. This study aims to assess the rate of the MetS and its associated factors in a nationally-representative sample of Iranian pediatric age groups. 3Methods: This nationwide cross-sectional study was designed in 2015 in 30 provinces of Iran. Participants consisted of 4,200 school students, aged 7-18 years, studied in a national school-based surveillance program (CASPIAN-V). Physical examination and laboratory tests were performed using standard protocols. Blood samples were drawn from 3834 students for biochemical tests.Results: The participation rate for blood sampling was 91.5%. MetS was significantly more prevalent among students in urban than in rural areas (5.7% vs. 4.8%, P value < 0.01). MetS was more prevalent in students with obese parents than in those with non-obese parents (6.4% vs. 4.5%, P value < 0.05). Significant association existed between moderate level of healthy nutritional behaviors and MetS after controlling for potential confounders (odds ratio [OR]: 0.62, 95% CI: 0.40-0.98). Students with high unhealthy nutritional behaviors showed an increased risk of MetS in crude (OR: 1.6, 95% CI: 1.05-2.44) and adjusted model (OR: 1.65, 95% CI: 1.05-2.63).Conclusion: High rate of MetS and associated risk factors was observed in Iranian pediatric age groups, with higher rates among boys. These findings provide useful information for effective preventive strategies based on diet, exercise, and lifestyle modification rather than therapeutic modalities.