Left ventricular function and volumes from gated [^13N]-ammonia positron emission tomography myocardial perfusion imaging: A prospective head-to-head comparison against CMR using a hybrid PET/MR device
Left ventricular function and volumes from gated [^13N]-ammonia positron emission tomography myocardial perfusion imaging: A prospective head-to-head comparison against CMR using a hybrid PET/MR device
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门控 [^13N]-氨正电子发射断层扫描心肌灌注成像的左心室功能和容量：使用混合 PET/MR 设备与 CMR 进行前瞻性头对头比较
DOI：
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发表时间：
2022
影响因子：
2.4
通讯作者：
T. Fuchs
中科院分区：
文献类型：
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作者：
Alexander Maurer;A. Šustar;A. Giannopoulos;H. Grünig;A. Bakula;D. Patriki;E. von Felten;M. Messerli;A. Pazhenkottil;C. Gebhard;P. Kaufmann;R. Buechel;T. Fuchs
背景 正电子发射断层扫描 (PET) 心肌灌注成像 (MPI) 可用于评估左心室 (LV) 体积和功能。我们对使用 [^13N]-氨-PET 和心脏磁共振 (CMR) 同时获得的左心室功能和体积进行了头对头比较，后者作为参考标准。方法和结果 在这项前瞻性研究中，51 名患者使用混合 PET/MR 设备接受了[^13N]-氨-PET MPI 和 CMR。对两种方法的左心室收缩末期容积 (LVESV)、舒张末期容积 (LVEDV)、每搏输出量 (LVSV)、射血分数 (LVEF) 和节段性室壁运动进行分析，并使用相关分析和 Bland-Altman (BA) 分析进行比较；使用方差分析比较节段性室壁运动。 [^13N]-氨-PET 和 CMR 的 LVEF 一致性良好，偏差极小 (−.6%)，BA 一致性限窄（−7.9% 至 6.8%），但 [^13N]-氨-PET 系统性地低估了 LV 容量，LVESV (−11.2 ml)、LVEDV (−28.9 ml) 和 LVEDV 方面存在较高偏差。 LVSV（− 17.5 毫升）。 [^13N]-氨-PET 中的平均节段室壁运动在 CMR 中相应的正常运动 (6.6 ± 2 mm)、低运动 (5.1 ± 2 mm) 和无运动 (3.3 ± 2 mm) 节段之间存在显着差异 ( P < .01)。结论 使用 [^13N]-氨-PET MPI 可以准确评估 LVEF 和 LV 室壁运动，但与 CMR 相比，LV 容量被显着低估。
Background Positron emission tomography (PET) myocardial perfusion imaging (MPI) can be used to evaluate left ventricular (LV) volumes and function. We performed a head-to-head comparison of LV function and volumes obtained simultaneously using [^13N]-ammonia-PET and cardiac magnetic resonance (CMR), with the latter serving as the reference standard. Methods and Results In this prospective study, 51 patients underwent [^13N]-ammonia-PET MPI and CMR using a hybrid PET/MR device. Left ventricular end-systolic volumes (LVESV), end-diastolic volumes (LVEDV), stroke volumes (LVSV), ejection fractions (LVEF), and segmental wall motion were analyzed for both methods and were compared using correlational and Bland-Altman (BA) analysis; segmental wall motion was compared using ANOVA. The agreement between [^13N]-ammonia-PET and CMR for LVEF was good, with minimal bias (− .6%) and narrow BA limits of agreement (− 7.9% to 6.8%), but [^13N]-ammonia-PET systematically underestimated LV volumes, with high bias in LVESV (− 11.2 ml), LVEDV (− 28.9 ml), and LVSV (− 17.5 ml). Mean segmental wall motion in [^13N]-ammonia-PET differed significantly among the corresponding normokinetic (6.6 ± 2 mm), hypokinetic (5.1 ± 2 mm), and akinetic (3.3 ± 2 mm) segments in CMR ( P < .01). Conclusion LVEF and LV wall motion can be accurately assessed using [^13N]-ammonia-PET MPI, although LV volumes are significantly underestimated compared to CMR.
DOI：
10.1016/j.jchf.2017.06.013
发表时间：
2017-11
期刊：
JACC. Heart failure
影响因子：
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作者：
Hsu JJ;Ziaeian B;Fonarow GC
通讯作者：
Fonarow GC