Peripheral hormonal responses to D-fenfluramine as a probe of central serotonergic function in humans
Peripheral hormonal responses to D-fenfluramine as a probe of central serotonergic function in humans
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DOI：
10.1007/s002130050863
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发表时间：
1999-02-01
影响因子：
3.4
通讯作者：
Cleare, AJ
中科院分区：
文献类型：
--
作者：
Abel, KM;Cleare, AJ
我们测试的假设，即D-芬氟拉明（DFEN）引起的皮质醇（CORT）的释放，在人类中可能介导的直接影响肾上腺预处理受试者与地塞米松（DEX），以防止释放促肾上腺皮质激素从垂体，随后由DFEN挑战测试。八名健康受试者（四名男性：四名女性）（平均年龄= 38.1 +/-8.4岁（SD））相隔> 1周（月经周期的相同阶段）进行研究，并且测试顺序是随机的。在使用DEX日（DEX+），受试者在晚上10点口服2 mg DEX;然后在上午9点口服30 mg DFEN，并在0-5 h采集样本用于PRL和CORT。通过从DFEN给药后的最大水平减去基线值来计算峰值激素反应（Delta值）。在两种测试条件之间比较峰值和基线激素值：在所有时间点比较DFEN诱导的CORT和PRL反应，有和没有DEX。两种试验条件（DEX-和DEX+）之间的Delta PRL无显著差异，但DEX后Delta CORT值显著降低：平均Delta CORT DEX- = 68.4 +/- 26.3 nmol/l，DEX+ = 0.0 nmol/l（均为钝性）（df 7.1; P = 0.03）。完全钝化的外周皮质醇反应表明，DFEN皮质醇反应是中央起源。
We tested the hypothesis that D-fenfluramine (DFEN)-elicited cortisol (CORT) release in humans may be mediated by a direct effect on the adrenal gland by pretreating subjects with dexamethasone (DEX), to prevent release of ACTH from the pituitary, followed by a DFEN challenge test. Eight healthy subjects (four males: four female) (mean age = 38.1 +/- 8.4 years (SD)] were studied > 1 week apart (same phase of menstrual cycle) and testing order was randomised. On the with-DEX day (DEX+), subjects took 2 mg DEX orally at 10 p.m.; 30 mg DFEN was then given orally at 9 a.m. and samples were taken at 0-5 h for PRL and CORT. Peak hormone responses (Delta values) were calculated by subtracting baseline values from the maximum levels post-DFEN administration. Peak and baseline hormonal values were compared between the two test conditions: DFEN-induced CORT and PRL responses were compared across all time points, with and without DEX. There was no significant difference in Delta PRL between the two test conditions (DEX- and DEX+), but Delta CORT values were significantly reduced after DEX: mean Delta CORT DEX- = 68.4 +/- 26.3 nmol/l, DEX+ = 0.0 nmol/l (all blunted) (df 7.1; P = 0.03). The completely blunted peripheral cortisol response indicates that DFEN cortisol responses are of central origin only.